妊娠早期暴露于他汀类药物与胎儿室间隔缺损有关。
Statin exposure during first trimester of pregnancy is associated with fetal ventricular septal defect.
机构信息
Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, United States of America.
Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, United States of America.
出版信息
Int J Cardiol. 2018 Oct 15;269:111-113. doi: 10.1016/j.ijcard.2018.07.002. Epub 2018 Jul 4.
BACKGROUND
A growing number of young women are exposed to statins during their first trimester of pregnancy. The goal of this study is to examine if first trimester statin exposure is associated with an increase in risk of fetal congenital cardiac anomalies.
METHODS
In a cohort of 379,238 pregnancies, we examined the risk of fetal congenital cardiac anomalies in association with maternal exposure to statin therapy during the first trimester of pregnancy using logistic regression models and propensity score matching methods.
RESULTS
280 women were exposed to statins. Congenital cardiac anomalies were present in 14 (5.0%) of pregnancies exposed to statin and 5282 (1.4%) of non-exposed pregnancies. First-trimester statin exposure was associated with an increased risk of ventricular septal defect (adjusted odds ratio [OR] 3.3, 95% confidence interval [CI]l 1.8-6.0, p < 0.001). This association was confirmed in an analysis using a propensity score-matched cohort (OR 4.7, 95% CI 2.0-10.8, p < 0.001).
CONCLUSIONS
Exposure to statins during the first trimester of pregnancy is associated with fetal ventricular septal defect.
背景
越来越多的年轻女性在怀孕的前三个月接触到他汀类药物。本研究的目的是检验妊娠早期接触他汀类药物是否会增加胎儿先天性心脏畸形的风险。
方法
在一个包含 379238 例妊娠的队列中，我们使用逻辑回归模型和倾向评分匹配方法，研究了母亲在妊娠早期接触他汀类药物治疗与胎儿先天性心脏畸形风险之间的关系。
结果
有 280 名女性接触了他汀类药物。在接触他汀类药物的妊娠中，有 14 例（5.0%）存在先天性心脏畸形，而在未接触他汀类药物的妊娠中，有 5282 例（1.4%）存在先天性心脏畸形。妊娠早期接触他汀类药物与室间隔缺损的风险增加相关（校正优势比 [OR] 3.3，95%置信区间 [CI] 1.8-6.0，p<0.001）。在使用倾向评分匹配队列的分析中也证实了这一关联（OR 4.7，95% CI 2.0-10.8，p<0.001）。
结论
妊娠早期接触他汀类药物与胎儿室间隔缺损有关。
Zotero 插件