Huang Zou-Qin, Li Tao
Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jun 20;38(6):761-764. doi: 10.3969/j.issn.1673-4254.2018.06.19.
To assess the clinical value of left ventricular Tei-index in early evaluation of cardiac function in hypertensive patients with left ventricular hypertrophy after radiochemotherapy.
Thirty hypertensive patients with malignancies and left ventricular hypertrophy and 30 hypertensive patients with malignancies without left ventricular hypertrophy were enrolled in this study, with 30 normotensive patients with malignancies as the control group. Left ventricular Tei-index and cardiac function indexes of the patients were detected using Doppler echocardiography before and after radiochemotherapy, and the changes in the cardiac function index and left ventricular Tei-index were compared among the 3 groups.
After radiochemotherapy, left ventricular Tei-index was significantly higher in hypertensive patients with left ventricular hypertrophy than in the control patients and hypertensive patients without left ventricular hypertrophy (P<0.05), and was similar between the latter two groups. No significant differences were found in the changes of left ventricular ejection fraction (EF), ratio of the early to late ventricular filling velocities (E/A ratio), or end-systolic volume (EDV) among the 3 groups after radiochemotherapy.
Tei-index is more sensitive than traditional echocardiography in assessing the changes of cardiac functions in hypertensive patients with left ventricular hypertrophy after chemotherapy.
评估左心室Tei指数在放化疗后左心室肥厚的高血压患者心功能早期评估中的临床价值。
本研究纳入30例合并恶性肿瘤且左心室肥厚的高血压患者、30例合并恶性肿瘤但无左心室肥厚的高血压患者，以30例合并恶性肿瘤的血压正常患者作为对照组。采用多普勒超声心动图检测患者放化疗前后的左心室Tei指数及心功能指标，并比较3组患者心功能指标及左心室Tei指数的变化。
放化疗后，左心室肥厚的高血压患者左心室Tei指数显著高于对照组及无左心室肥厚的高血压患者（P<0.05），而后两组相似。放化疗后3组患者的左心室射血分数（EF）、心室充盈早期与晚期速度比值（E/A比值）或收缩末期容积（EDV）变化差异均无统计学意义。
Tei指数在评估放化疗后左心室肥厚的高血压患者心功能变化方面比传统超声心动图更敏感。
