Zhou Haixia, Zhuo Zhenjian, Chen Shanshan, Zhao Jie, Mo Yixiao, Zhang Jiao, He Jing, Ruan Jichen
Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China,
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Cancer Manag Res. 2018 Jul 2;10:1807-1816. doi: 10.2147/CMAR.S168515. eCollection 2018.
Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The oncogene is amplified in some neuroblastoma patients and correlated with poor prognosis. However, less is known regarding the relationship between gene single-nucleotide polymorphisms (SNPs) and neuroblastoma risk.
To investigate the contribution of gene polymorphisms to neuroblastoma risk, we performed a 3-center case-control study by genotyping 4 SNPs in the gene from 429 cases and 884 controls.
The results showed that only rs57961569 G>A was associated with neuroblastoma risk (GA vs GG: adjusted odds ratio =0.76, 95% confidence interval =0.60-0.98, =0.033), while the other 3 SNPs were not (rs9653226 T>C, rs13034994 A>G, and rs60226897 G>A). Stratified analysis revealed that rs57961569 GG carriers were more likely to develop neuroblastoma in the following subgroups: children older than 18 months, tumor derived from the adrenal gland, and clinical stages III + IV. The increased neuroblastoma risk associated with the rs9653226 variant CC genotypes was more evident in the following subgroups: females, tumor derived from the adrenal gland, and clinical stages III + IV. The presence of 2-3 risk genotypes had a significant relationship with the following subgroups: tumor derived from the adrenal gland and clinical stages III + IV.
This study demonstrates a weak impact of gene polymorphisms on neuroblastoma risk, which should be further validated.
神经母细胞瘤是一种交感神经系统的胚胎性肿瘤。某些神经母细胞瘤患者中该癌基因会发生扩增，且与预后不良相关。然而，关于该基因单核苷酸多态性（SNP）与神经母细胞瘤风险之间的关系，人们了解较少。
为了研究该基因多态性对神经母细胞瘤风险的影响，我们进行了一项3中心病例对照研究，对429例病例和884例对照的该基因中的4个SNP进行基因分型。
结果显示，只有rs57961569 G>A与神经母细胞瘤风险相关（GA与GG相比：校正比值比=0.76，95%置信区间=0.60-0.98，P=0.033），而其他3个SNP（rs9653226 T>C、rs13034994 A>G和rs60226897 G>A）则无此关联。分层分析显示，rs57961569 GG携带者在以下亚组中更易发生神经母细胞瘤：18个月以上儿童、肾上腺来源的肿瘤以及临床分期III+IV期。rs9653226变异CC基因型与神经母细胞瘤风险增加在以下亚组中更为明显：女性、肾上腺来源的肿瘤以及临床分期III+IV期。存在2-3种风险基因型与以下亚组显著相关：肾上腺来源的肿瘤和临床分期III+IV期。
本研究表明该基因多态性对神经母细胞瘤风险的影响较弱，这一点有待进一步验证。
