Hara Takeshi, Ogata Takeshi, Wada Hiroko, Yabuki Takayuki, Kanazawa Susumu
Department of Radiology, NHO Iwakuni Clinical Center, Yamaguchi.
Department of Radiology, Okayama University, Okayama, Japan.
Curr Urol. 2018 Jun;11(4):201-205. doi: 10.1159/000447219. Epub 2018 Mar 30.
Gadobutrol (Gd-DO3A-butrol) (Gadovist®) is a macrocyclic gadolinium-based contrast agent for magnetic resonance imaging (MRI) formulated at 1.0 mmol Gd/ml. Gadobutrol's higher concentration compared to other contrast agents (0.5 mmol Gd/ml) is associated with higher T1 relaxivity. We examined whether gadobutrol increases the accuracy of prostate cancer detection using dynamic contrast-enhanced MRI.
Multiparametric MRI was performed in 379 patients: 94 patients received 1 M gadobutrol while 285 randomly received equivalent doses of 0.5 M gadoterate meglumine or gadopentetate dimeglumine. MRI images were retrospectively and blindly assessed for the presence of cancer by comparing them with prostate biopsy findings.
The specificity and accuracy were significantly higher with 1 M gadobutrol than 0.5 M of the other contrast agents. There were no significant differences in the sensitivity, or positive and negative predictive values.
Multiparametric MRI using 1 M gadobutrol may improve the accuracy of prostate cancer detection.
钆布醇（Gd-DO3A-布醇）（佳迪维®）是一种用于磁共振成像（MRI）的大环钆基造影剂，其浓度为1.0 mmol Gd/ml。与其他造影剂（0.5 mmol Gd/ml）相比，钆布醇的浓度更高，这与更高的T1弛豫率相关。我们研究了钆布醇是否能提高动态对比增强MRI检测前列腺癌的准确性。
对379例患者进行了多参数MRI检查：94例患者接受了1 M钆布醇，而285例患者随机接受了等效剂量的0.5 M钆喷酸葡胺或钆双胺。通过将MRI图像与前列腺活检结果进行比较，对其进行回顾性和盲法评估，以确定是否存在癌症。
1 M钆布醇的特异性和准确性显著高于0.5 M的其他造影剂。敏感性、阳性和阴性预测值无显著差异。
使用1 M钆布醇的多参数MRI可能会提高前列腺癌检测的准确性。
