超重和肥胖女性孕期母体尿酮的患病率
Prevalence of maternal urinary ketones in pregnancy in overweight and obese women.
作者信息
Robinson Helen L, Barrett Helen L, Foxcroft Katie, Callaway Leonie K, Dekker Nitert Marloes
机构信息
UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
Obstetric Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
出版信息
Obstet Med. 2018 Jun;11(2):79-82. doi: 10.1177/1753495X17743163. Epub 2017 Dec 5.
BACKGROUND
Ketonuria may be associated with adverse fetal outcomes. This study aimed to determine the prevalence of ketonuria at three time points in pregnancy and to assess whether ketonuria correlates with a clinical indication for performing a urine test.
METHODS
Women had fasting urinary ketone levels measured at 16 and 28 weeks gestation and random ketone levels measured close to 36 weeks gestation. All ketone levels in the third trimester were recorded along with the clinical indication for the test.
RESULTS
One hundred and eighty-seven women were included in the study. Twenty-two per cent of women had ketonuria at either 16 or 28 weeks gestation and 8% at 36 weeks gestation. Ketonuria was significantly more likely if a test was performed for a clinical indication ( = 0.0002).
CONCLUSION
Ketonuria in pregnancy is common affecting at least one in five women. Ketonuria is more common in women who have a clinical indication for performing a urine test.
背景
酮尿症可能与不良胎儿结局相关。本研究旨在确定孕期三个时间点酮尿症的患病率，并评估酮尿症是否与进行尿液检测的临床指征相关。
方法
在妊娠16周和28周时测量孕妇空腹尿酮水平，在接近妊娠36周时测量随机尿酮水平。记录孕晚期所有酮水平以及检测的临床指征。
结果
187名女性纳入研究。22%的女性在妊娠16周或28周时出现酮尿症，36周时为8%。如果因临床指征进行检测，则出现酮尿症的可能性显著更高（P = 0.0002）。
结论
孕期酮尿症很常见，至少五分之一的女性受影响。有进行尿液检测临床指征的女性中酮尿症更常见。
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