Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
J Korean Med Sci. 2010 Dec;25(12):1771-6. doi: 10.3346/jkms.2010.25.12.1771. Epub 2010 Nov 24.
Obese individuals are less able to oxidize fat than non-obese individuals. Caloric reduction or fasting can detect ketonuria. We investigated the differences of metabolic parameters in the presence of ketonuria after a minimum 8 hr fast in a cross-sectional analysis of 16,523 Koreans (6,512 women and 10,011 men). The relationship between the presence of ketonuria of all subjects and prevalence of obesity, central obesity, metabolic syndrome, and obesity-related metabolic parameters were assessed. The ketonuria group had lower prevalence of obesity, central obesity, and metabolic syndrome than the non-ketonuria group. In addition, all metabolic parameters (including body weight, waist circumference, blood glucose, high-density lipoprotein, triglyceride, blood pressure, and insulin) were favorable in the ketonuria group than in the non-ketonuria group, even after adjustment for age, tobacco use, and alcohol consumption. The odds ratios of having obesity (odds ratio [OR]=1.427 in women, OR=1.582 in men, P<0.05), central obesity (OR=1.675 in women, OR=1.889 in men, P<0.05), and metabolic syndrome (OR=3.505 in women, OR=1.356 in men, P<0.05) were increased in the non-ketonuria group compared to the ketonuria group. The presence of ketonuria after at least an 8 hr fast may be indicative of metabolic superiority.
肥胖个体的脂肪氧化能力低于非肥胖个体。减少热量摄入或禁食可检测到酮尿症。我们在横断面分析了 16523 名韩国人（6512 名女性和 10011 名男性）后，研究了禁食至少 8 小时后出现酮尿症时代谢参数的差异。评估了所有受试者中酮尿症的存在与肥胖、中心性肥胖、代谢综合征以及与肥胖相关的代谢参数的患病率之间的关系。酮尿症组的肥胖、中心性肥胖和代谢综合征的患病率低于非酮尿症组。此外，与非酮尿症组相比，酮尿症组的所有代谢参数（包括体重、腰围、血糖、高密度脂蛋白、甘油三酯、血压和胰岛素）均更为有利，即使在调整年龄、吸烟和饮酒后也是如此。与酮尿症组相比，非酮尿症组发生肥胖（女性的比值比 [OR]=1.427，男性的 OR=1.582，P<0.05）、中心性肥胖（女性的 OR=1.675，男性的 OR=1.889，P<0.05）和代谢综合征（女性的 OR=3.505，男性的 OR=1.356，P<0.05）的几率更高。至少禁食 8 小时后出现酮尿症可能表明代谢更为优越。
