Collie G W, Pulka-Ziach K, Guichard G
Univ. Bordeaux , CBMN , UMR 5248 , Institut Européen de Chimie et Biologie , 2 rue Robert Escarpit , 33607 Pessac , France . Email:
CNRS , CBMN , UMR 5248 , F-33600 , Pessac , France.
Chem Sci. 2016 May 1;7(5):3377-3383. doi: 10.1039/c6sc00090h. Epub 2016 Feb 10.
X-ray crystallography has played a major role in the advancement of foldamer research, however, obtaining well-formed single crystals of suitable quality for structure determination by X-ray diffraction methods is often rather challenging. Towards this end, we report here the ability of common surfactants to promote the crystallisation of a series of water-soluble oligourea foldamers which had previously proven highly resistant to crystallisation. Four high-resolution crystal structures are reported, suggesting certain surfactants could be potentially useful tools for the crystallisation of intractable water-soluble foldamers (or peptides).
X射线晶体学在折叠体研究的进展中发挥了重要作用，然而，通过X射线衍射方法获得用于结构测定的高质量、形状良好的单晶往往颇具挑战性。为此，我们在此报告常见表面活性剂促进一系列水溶性寡脲折叠体结晶的能力，这些折叠体此前已证明极难结晶。本文报道了四个高分辨率晶体结构，表明某些表面活性剂可能是使难处理的水溶性折叠体（或肽）结晶的潜在有用工具。
