Nakayama Shoko, Matsuda Mitsuhiro, Adachi Tatsuya, Sueda Sanae, Ueda Kayo, Kawahara Kunimitsu, Ohashi Yuka, Awaji Sumie, Hashimoto Shigeo, Matsumura Itaru
Department of Hematology, PL General Hospital, 2204, Shindo, Tondabayashi City, Osaka 584-8585, Japan.
Department of Pathology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Osaka 583-8588, Japan.
Leuk Res Rep. 2018 Jun 28;10:1-3. doi: 10.1016/j.lrr.2018.06.001. eCollection 2018.
A 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. This is the first case report of TNF- and IL-6-producing aggressive HGBL, NOS in the pleura, in which radiological findings mimicked pleural mesothelioma. The aggressive tumor progression in the present case may have been caused by abnormal cytokine production from lymphoma cells.
一名65岁男性因左侧胸痛、背痛和呼吸困难入院。计算机断层扫描显示左侧胸膜明显环形增厚。胸腔镜胸膜活检诊断为高级别B细胞淋巴瘤，非特指型（HGBL，NOS）。淋巴瘤细胞肿瘤坏死因子（TNF）和白细胞介素-6呈阳性。这是首例关于胸膜中产生TNF和IL-6的侵袭性HGBL，NOS的病例报告，其影像学表现类似胸膜间皮瘤。本例中侵袭性肿瘤进展可能是由淋巴瘤细胞异常产生细胞因子所致。
