对有患乳腺癌高风险的女性进行保留乳头的乳房切除术。
Nipple-sparing mastectomy in women at high risk of developing breast cancer.
作者信息
Lewis Rebecca S, George Angela, Rusby Jennifer E
机构信息
Department of Breast Surgery, Royal Marsden NHS Foundation Trust and the Institute for Cancer Research, Sutton, UK.
Department of Cancer Genetics, Institute for Cancer Research and the Royal Marsden Hospital NHS Foundation Trust, Sutton, UK.
出版信息
Gland Surg. 2018 Jun;7(3):325-336. doi: 10.21037/gs.2018.04.01.
Abstract
Nipple-sparing mastectomy is a valuable addition to the options available for women at high risk of developing breast cancer. In this review, we summarize current knowledge about the high-risk genes, , and and the associated guidelines with regard to risk-reducing surgery. We consider other genetic risks and high-risk lesions. We discuss the literature on bilateral mastectomy for breast cancer risk-reduction, and the results of nipple-sparing mastectomy in particular. Finally, we report on patient satisfaction with these procedures and the impact that nipple-sparing mastectomy may have on women at high-risk of breast cancer.
摘要
保留乳头的乳房切除术是为罹患乳腺癌高风险的女性提供的多种选择中一项有价值的补充。在本综述中，我们总结了关于高危基因、以及与降低风险手术相关的指南的现有知识。我们考虑了其他遗传风险和高危病变。我们讨论了关于双侧乳房切除术以降低乳腺癌风险的文献，特别是保留乳头的乳房切除术的结果。最后，我们报告了患者对这些手术的满意度以及保留乳头的乳房切除术可能对乳腺癌高危女性产生的影响。
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