Department of Chemistry, Jinan University, Guangzhou 510632, China.
Chem Commun (Camb). 2018 Aug 21;54(68):9394-9397. doi: 10.1039/c8cc04021d.
A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.
一种带负电荷并靶向细胞核的 DNA 四面体被合理设计并用作带正电荷的金属配合物的纳米载体。这种四面体通过触发与血管模拟相关的信号通路，加速金属配合物进入细胞核的转运，并抑制神经胶质瘤细胞的生长和侵袭，从而实现精确的神经胶质瘤治疗。
