四面体 DNA 纳米结构在癌症治疗中的有效性：进展与展望。

Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, 266021, China.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.

J Nanobiotechnology. 2021 Dec 7;19(1):412. doi: 10.1186/s12951-021-01164-0.

Recently, DNA nanostructures with vast application potential in the field of biomedicine, especially in drug delivery. Among these, tetrahedral DNA nanostructures (TDN) have attracted interest worldwide due to their high stability, excellent biocompatibility, and simplicity of modification. TDN could be synthesized easily and reproducibly to serve as carriers for, chemotherapeutic drugs, nucleic acid drugs and imaging probes. Therefore, their applications include, but are not restricted to, drug delivery, molecular diagnostics, and biological imaging. In this review, we summarize the methods of functional modification and application of TDN in cancer treatment. Also, we discuss the pressing questions that should be targeted to increase the applicability of TDN in the future.

最近，DNA 纳米结构在生物医药领域具有广泛的应用潜力，特别是在药物输送方面。其中，四面体 DNA 纳米结构 (TDN) 因其高稳定性、优异的生物相容性和简单的修饰性而引起了全球的关注。TDN 可以很容易地合成和重复合成，用作化疗药物、核酸药物和成像探针的载体。因此，它们的应用包括但不限于药物输送、分子诊断和生物成像。在这篇综述中，我们总结了 TDN 在癌症治疗中的功能修饰和应用方法。此外，我们还讨论了未来应该针对哪些紧迫问题来提高 TDN 的适用性。