Wright C M, Marryat L, McColl J, Harjunmaa U, Cole T J
School of Medicine, College of MVLS, University of Glasgow, Glasgow, UK.
School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.
Pediatr Obes. 2018 Oct;13(10):621-627. doi: 10.1111/ijpo.12427. Epub 2018 Jul 11.
To investigate whether high weight in infancy predicts obesity in childhood.
Data from two UK cohorts (Newcastle Growth and Development N = 795, Gateshead Millennium N = 393) and one Finnish (Tampere N = 1262) were combined. Z scores of weight at 3 and 12 months and body mass index (BMI) at 5 and 8 years were categorized as raised/overweight (1 to <2 SD) or high/obese (≥2 SD).
The majority of infants with raised or high weight at birth tended to revert to normal by 3 months and to track in the same category from 3 to 12 months. Although infants with high weight were five times more likely to have BMI ≥ 2 SD at 8 years (p < 0.001), only 22% went on to have BMI ≥ 2 SD, while 64% of infants with raised weight had normal BMI at 8 years. Of children with BMI ≥ 2 SD aged 8 years, only 22% had raised weight in infancy and half had BMI ≥ 2 SD for the first time at that age.
Infants with raised weight in infancy tend to remain so, but most children who go on to have BMI ≥ 2 SD were not unusually heavy infants and the majority of infants with high weight reverted to overweight or normal weight in childhood.
研究婴儿期体重过高是否可预测儿童期肥胖。
合并了来自两个英国队列（纽卡斯尔生长与发育队列，N = 795；盖茨黑德千禧队列，N = 393）和一个芬兰队列（坦佩雷队列，N = 1262）的数据。将3个月和12个月时的体重Z评分以及5岁和8岁时的体重指数（BMI）分为升高/超重（1至<2标准差）或高/肥胖（≥2标准差）。
大多数出生时体重升高或过高的婴儿在3个月时倾向于恢复正常，并在3至12个月期间保持在同一类别。尽管体重高的婴儿在8岁时BMI≥2标准差的可能性是其他婴儿的5倍（p < 0.001），但只有22%的婴儿BMI≥2标准差，而64%体重升高的婴儿在8岁时BMI正常。在8岁时BMI≥2标准差的儿童中，只有22%在婴儿期体重升高，一半是在该年龄首次出现BMI≥2标准差。
婴儿期体重升高的婴儿往往保持这种状态，但大多数BMI≥2标准差的儿童在婴儿期体重并非异常高，大多数体重高的婴儿在儿童期恢复为超重或正常体重。
