Nasal high-frequency oscillatory ventilation and CO removal: A randomized controlled crossover trial.

OBJECTIVE

To compare short-term application of nasal high-frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP).

WORKING HYPOTHESIS

nHFOV improves CO removal with respect to nCPAP in preterm infants needing noninvasive respiratory support and persistent oxygen supply after the first 72 h of life.

STUDY DESIGN

Multicenter non-blinded prospective randomized crossover study.

PATIENT SELECTION

Thirty premature infants from eight tertiary neonatal intensive care units, of mean ± SD 26.4 ± 1.8 weeks of gestational age and 921 ± 177 g of birth weight.

METHODOLOGY

Infants were randomly allocated in a 1:1 ratio to receive a starting treatment mode of either nCPAP or nHFOV delivered by the ventilator CNO (Medin, Germany), using short binasal prongs of appropriate size. A crossover design with four 1-h treatment periods was used, such that each infant received both treatments twice. The primary outcome was the mean transcutaneous partial pressure of CO (TcCO ) value during the 2-h cumulative period of nHFOV compared with the 2-h cumulative period of nCPAP.

RESULTS

Significantly lower TcCO values were observed during nHFOV compared with nCPAP: 47.5 ± 7.6 versus 49.9 ± 7.2 mmHg, respectively, P = 0.0007. A different TcCO behavior was found according to the random sequence: in patients starting on nCPAP, TcCO significantly decreased from 50.0 ± 8.0 to 46.6 ± 7.5 mmHg during nHFOV (P = 0.001). In patients starting on nHFOV, TcCO slightly increased from 48.5 ± 7.8 to 49.9 ± 6.7 mmHg during nCPAP (P = 0.13).

CONCLUSIONS

nHFOV delivered through nasal prongs is more effective than nCPAP in improving the elimination of CO .