Information in this record refers to the use of iothalamate sodium I 125 as a kidney function diagnostic agent. No information is available on the use of iothalamate sodium I 125 during breastfeeding. However, the biologic half-life of iothalamate after intravenous administration is 1.5 hours with normal kidney function, so the drug will be almost completely eliminated from the body in 8 hours. This time may be longer in patients with impaired kidney function and in patients who receive the drug by subcutaneous injection.[1] If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[2-4] Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels, they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[5]
本记录中的信息涉及使用碘他拉酸钠I 125作为肾功能诊断剂。关于哺乳期使用碘他拉酸钠I 125的信息尚无。然而，静脉给药后碘他拉酸钠在肾功能正常时的生物半衰期为1.5小时，因此药物将在8小时内几乎完全从体内消除。在肾功能受损的患者以及通过皮下注射接受该药物的患者中，这个时间可能会更长。[1]如果母亲在检查前已挤出并保存乳汁，她可以在哺乳中断期间喂给婴儿。[2-4]担心乳汁中放射性水平的母亲可以要求在其医院的核医学设施进行检测。当放射性处于本底水平时，她们可以安全地恢复母乳喂养。一种测量乳汁放射性并确定母亲可安全恢复母乳喂养时间的方法已经发表。[5]
