Milk levels of imipramine and its metabolite are low and have not been detected in the serum of breastfed infants. Immediate side effects have not been reported and a limited amount of follow-up has found no adverse effects on infant growth and development. Imipramine use during breastfeeding would usually not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. A safety scoring system finds imipramine use to be possible during breastfeeding.[1] Some experts consider imipramine one of the antidepressants of choice for nursing mothers.[2] However, other agents may be preferred when large doses are required or while nursing a newborn or preterm infant.
丙咪嗪及其代谢产物在乳汁中的含量较低，且在母乳喂养婴儿的血清中未检测到。尚未有关于即刻副作用的报道，有限的随访发现对婴儿生长发育无不良影响。母乳喂养期间使用丙咪嗪通常预计不会对母乳喂养的婴儿造成任何不良影响，尤其是如果婴儿年龄超过2个月。一种安全评分系统认为母乳喂养期间可以使用丙咪嗪。[1] 一些专家认为丙咪嗪是哺乳期母亲首选的抗抑郁药之一。[2] 然而，当需要大剂量用药或喂养新生儿或早产儿期间，可能更倾向于使用其他药物。
