Because of its sedating potential, active metabolite, presence in infant serum, two reports of adverse effects in breastfed infants, and only one report of use without apparent adverse reactions, doxepin is a poor choice and other agents are preferred, especially while nursing a newborn or preterm infant. A safety scoring system finds doxepin to be not recommended during breastfeeding.[1] Maternal use of topical doxepin cream is unlikely to pose a problem for a breastfed infant as long as it is applied away from the breasts so that the infant cannot ingest the drug directly.
由于其具有镇静作用、存在活性代谢物、可在婴儿血清中检测到、有两例关于母乳喂养婴儿出现不良反应的报告，且仅有一例使用后未出现明显不良反应的报告，多塞平不是一个好的选择，其他药物更为可取，尤其是在哺育新生儿或早产儿期间。一种安全评分系统认为母乳喂养期间不建议使用多塞平。[1] 只要将外用多塞平乳膏涂抹在远离乳房的部位，使婴儿无法直接摄入药物，母亲使用该乳膏对母乳喂养婴儿不太可能造成问题。
Zotero 插件