No published information exists on the use of pitavastatin during breastfeeding. It is 99% bound to plasma proteins, so amounts in milk are likely low. Because of a concern with disruption of infant lipid metabolism, the consensus is that pitavastatin should not be used during breastfeeding. However, others have argued that children homozygous for familial hypercholesterolemia are treated with statins beginning at 1 year of age, that statins have low oral bioavailability, and risks to the breastfed infant are low, especially with rosuvastatin and pravastatin.[1] Until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
关于匹伐他汀在母乳喂养期间的使用，目前尚无已发表的信息。它与血浆蛋白的结合率为99%，因此乳汁中的含量可能较低。出于对婴儿脂质代谢紊乱的担忧，目前的共识是母乳喂养期间不应使用匹伐他汀。然而，也有人认为，患有家族性高胆固醇血症的纯合子儿童从1岁起就开始使用他汀类药物治疗，他汀类药物的口服生物利用度较低，对母乳喂养婴儿的风险较低，尤其是瑞舒伐他汀和普伐他汀。[1]在获得更多数据之前，可能更倾向于使用替代药物，尤其是在哺乳新生儿或早产儿期间。
Zotero 插件