A novel 8-phenyl-substituted xanthine derivative is a selective antagonist at adenosine A1-receptors in vivo.
作者信息
Jakobson K A, Kirk K L, Daly J W, Jonzon B, Li Y O, Fredholm B B
出版信息
Acta Physiol Scand. 1985 Oct;125(2):341-2. doi: 10.1111/j.1748-1716.1985.tb07725.x.
Abstract
摘要
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A novel 8-phenyl-substituted xanthine derivative is a selective antagonist at adenosine A1-receptors in vivo.一种新型的8-苯基取代黄嘌呤衍生物在体内是腺苷A1受体的选择性拮抗剂。
Acta Physiol Scand. 1985 Oct;125(2):341-2. doi: 10.1111/j.1748-1716.1985.tb07725.x.
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Inhibition by xanthine derivatives of adenosine receptor-stimulated cyclic adenosine 3',5'-monophosphate accumulation in rat and guinea-pig thymocytes.黄嘌呤衍生物对大鼠和豚鼠胸腺细胞中腺苷受体刺激的环磷酸腺苷积累的抑制作用。
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Influences of different adenosine receptor subtypes on catalepsy in mice.不同腺苷受体亚型对小鼠僵住症的影响。
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Apparent affinity of some 8-phenyl-substituted xanthines at adenosine receptors in guinea-pig aorta and atria.某些8-苯基取代黄嘌呤对豚鼠主动脉和心房中腺苷受体的表观亲和力。
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XAC, a functionalized congener of 1,3-dialkylxanthine, antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro.XAC是1,3 - 二烷基黄嘌呤的一种功能化同系物，在体外可拮抗A1腺苷受体介导的肾素分泌抑制作用。
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[3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors.1,3 - 二丙基 - 8 - 苯基黄嘌呤的[3H]黄嘌呤胺类似物：一种腺苷受体拮抗剂放射性配体。
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Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells.1,3 - 二丙基 - 8 - 苯基黄嘌呤的功能化类似物：对调节嗜铬细胞瘤细胞、血小板和脂肪细胞膜腺苷酸环化酶的腺苷受体具有强效拮抗作用。
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8
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.二元药物：嘌呤与一种能同时结合腺苷和P物质受体的肽的缀合物。
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9
Evidence that a novel 8-phenyl-substituted xanthine derivative is a cardioselective adenosine receptor antagonist in vivo.一种新型8-苯基取代黄嘌呤衍生物在体内是心脏选择性腺苷受体拮抗剂的证据。
J Cardiovasc Pharmacol. 1987 Apr;9(4):396-400. doi: 10.1097/00005344-198704000-00003.
本文引用的文献
1
Adenosine receptors.
Med Biol. 1982 Dec;60(6):289-93.
2
Xanthine derivatives as adenosine receptor antagonists.作为腺苷受体拮抗剂的黄嘌呤衍生物。
Eur J Pharmacol. 1982 Jul 30;81(4):673-6. doi: 10.1016/0014-2999(82)90359-4.
3
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.1,3 - 二烷基黄嘌呤的功能化类似物：对腺苷受体具有高亲和力的类似物的制备
J Med Chem. 1985 Sep;28(9):1334-40. doi: 10.1021/jm00147a038.
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