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剂量学在精准医学中的相关性。

The Relevance of Dosimetry in Precision Medicine.

机构信息

Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Würzburg, Würzburg, Germany

Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Würzburg, Würzburg, Germany.

出版信息

J Nucl Med. 2018 Oct;59(10):1494-1499. doi: 10.2967/jnumed.117.206649. Epub 2018 Jul 12.

DOI:10.2967/jnumed.117.206649
PMID:30002109
Abstract

The aim of this review is to provide an overview of the most recent technologic developments in state-of-the-art equipment and tools for dosimetry in radionuclide therapies. This includes, but is not restricted to, calibration methods for imaging systems. In addition, a summary of new developments that consider the influence of small-scale dosimetry and of biologic effects on radionuclide therapies is given. Finally, the current limitations of patient-specific dosimetry such as bone-marrow dosimetry or dosimetry of α-emitters are discussed.

摘要

本次综述旨在概述放射性核素治疗中最新的先进设备和工具的技术发展。这包括但不限于成像系统的校准方法。此外,还总结了考虑小尺度剂量学和生物效应对放射性核素治疗影响的新发展。最后,讨论了患者特异性剂量学的当前局限性,如骨髓剂量学或α发射器剂量学。

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