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Fresh approaches to vaccine development: New financial and economic models are required to bring more vaccines against a wider range of diseases to the market.创新疫苗研发模式：需要新的财务和经济模式，以将更多针对更广泛疾病的疫苗推向市场。
EMBO Rep. 2018 Aug;19(8). doi: 10.15252/embr.201846675. Epub 2018 Jul 12.
2
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Emerging infectious diseases: A proactive approach.新发传染病：主动应对。
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4055-4059. doi: 10.1073/pnas.1701410114. Epub 2017 Apr 10.
2
Prioritizing vaccines for developing world diseases.优先考虑针对发展中世界疾病的疫苗。
Vaccine. 2017 Jan 20;35 Suppl 1:A16-A19. doi: 10.1016/j.vaccine.2016.10.087. Epub 2016 Dec 22.
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Preparing for the next Zika.为应对下一次寨卡疫情做准备。
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Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial.rVSV- 载体疫苗表达埃博拉表面糖蛋白的功效和效果：来自几内亚环疫苗接种群组随机对照试验的中期结果。
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Establishing a Global Vaccine-Development Fund.建立一个全球疫苗开发基金。
N Engl J Med. 2015 Jul 23;373(4):297-300. doi: 10.1056/NEJMp1506820.
6
A global biomedical R&D fund and mechanism for innovations of public health importance.一个用于具有公共卫生重要性的创新的全球生物医学研发基金及机制。
PLoS Med. 2015 May 11;12(5):e1001831. doi: 10.1371/journal.pmed.1001831. eCollection 2015 May.
7
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses.减毒活重组疫苗可保护非人灵长类动物免受埃博拉病毒和马尔堡病毒感染。
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创新疫苗研发模式：需要新的财务和经济模式，以将更多针对更广泛疾病的疫苗推向市场。

Fresh approaches to vaccine development: New financial and economic models are required to bring more vaccines against a wider range of diseases to the market.

机构信息

EMBO, Heidelberg, Germany.

出版信息

EMBO Rep. 2018 Aug;19(8). doi: 10.15252/embr.201846675. Epub 2018 Jul 12.

DOI:10.15252/embr.201846675
PMID:30002117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6073068/
Abstract

Many promising vaccine candidates have not made it to the market, owing to economic rather than scientific factors. Market incentives, shared responsibility, and novel technologies could spur innovation to develop vaccines against a wider range of diseases. [Image: see text]

摘要

许多有前途的疫苗候选者由于经济而非科学因素而未能上市。市场激励、共同责任和新技术可以激发创新，开发针对更广泛疾病的疫苗。[图片：见正文]