Saul Allan, O'Brien Katherine L
GSK Vaccines Institute for Global Health, Siena, Italy.
International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Vaccine. 2017 Jan 20;35 Suppl 1:A16-A19. doi: 10.1016/j.vaccine.2016.10.087. Epub 2016 Dec 22.
A major disparity in the burden of health will need to be addressed to achieve the "Grand Convergence" by 2035. In particular people living in low and middle income countries have a much higher burden of infectious diseases. Although vaccines have been very effective in reducing the global burden of infectious disease, there are no registered vaccines to address 60% of the current burden of infectious disease, especially in developing countries. Thus there is a pressing need for new vaccines and for prioritizing vaccine development given that resources for developing new vaccines are strictly limited. As part of the GLOBAL HEALTH 2035: Mission Grand Convergence meeting one working group assessed the SMART vaccine algorithm as a mechanism for prioritizing vaccine development for diseases of priority in the developing world. In particular, the working group considered which criteria in the standard SMART set were considered "key" criteria and whether other criteria should be considered, when prioritizing vaccines for this important set of countries.
为了在2035年实现“大融合”，需要解决健康负担方面的重大差距。特别是生活在低收入和中等收入国家的人们，传染病负担要高得多。尽管疫苗在减轻全球传染病负担方面非常有效，但目前60%的传染病负担尚无注册疫苗可应对，尤其是在发展中国家。鉴于开发新疫苗的资源严格受限，因此迫切需要新疫苗并对疫苗研发进行优先排序。作为“2035年全球健康：大融合使命”会议的一部分，一个工作组评估了SMART疫苗算法，将其作为为发展中世界重点疾病的疫苗研发进行优先排序的一种机制。特别是，该工作组考虑了标准SMART集中的哪些标准被视为“关键”标准，以及在为这一重要国家群体确定疫苗优先顺序时是否应考虑其他标准。
