Yutani Chikao, Nagano Teruaki, Komatsu Sei, Kodama Kazuhisa
Department of Pathology, Amagasaki Central Hospital, Amagasaki, Japan.
Department of Pathology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
BMJ Case Rep. 2018 Jul 11;2018:bcr-2018-225558. doi: 10.1136/bcr-2018-225558.
The number of released free cholesterol crystal emboli (fCCE) and their role during percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) have not been documented yet. Furthermore, fCCE manifesting in the coronary lumen following plaque rupture has been historically overlooked owing to the standard tissue preparation for light microscopy which uses ethanol as a dehydrating agent that can dissolve fCCE, leaving behind empty tissue. In this case report, we evaluated fCCE released during PCI for ACS and their relationship with myocardial injury and coronary artery obstruction on the H&E-stained sections by using polarised light microscopy. To our knowledge, there has been no mention of the visibility of fCCE on H&E-stained frozen polarised sections before.
游离胆固醇结晶栓子（fCCE）的释放数量及其在急性冠状动脉综合征（ACS）经皮冠状动脉介入治疗（PCI）过程中的作用尚未见报道。此外，由于用于光学显微镜检查的标准组织制备方法使用乙醇作为脱水剂，而乙醇会溶解fCCE，导致组织中空，因此斑块破裂后在冠状动脉腔内出现的fCCE在历史上一直被忽视。在本病例报告中，我们通过偏振光显微镜评估了ACS患者PCI期间释放的fCCE及其与苏木精-伊红（H&E）染色切片中心肌损伤和冠状动脉阻塞的关系。据我们所知，此前尚无关于H&E染色冰冻偏振切片上fCCE可见性的报道。
