Gabourel J D, Moore M A, Bagby G C, Davies G H
Arthritis Rheum. 1977 Jan-Feb;20(1):59-64. doi: 10.1002/art.1780200112.
Sodium salicylate inhibited generation of granulocyte and macrophage colonies when added to soft agar cultures of mouse or human bone marrow cells (CFUc) containing colony-stimulating factor (CSF). This effect was dose-dependent with over 90% inhibition at 48 mg%. The salicylate effect was not decreased with increasing concentrations of CSF, but inhibition was reversed when salicylate-treated CFUc were washed with drug-free medium before plating. CSF production was not inhibited by salicylate.
当将水杨酸钠添加到含有集落刺激因子（CSF）的小鼠或人骨髓细胞（CFUc）的软琼脂培养物中时，它会抑制粒细胞和巨噬细胞集落的生成。这种作用呈剂量依赖性，在48mg%时抑制率超过90%。随着CSF浓度的增加，水杨酸盐的作用并未减弱，但当用不含药物的培养基洗涤经水杨酸盐处理的CFUc后再接种时，抑制作用会逆转。水杨酸盐不会抑制CSF的产生。
