非甾体抗炎药在分子水平上的作用
Effects of Nonsteroidal Anti-Inflammatory Drugs at the Molecular Level.
作者信息
Gunaydin Caner, Bilge S Sirri
机构信息
Department of Pharmacology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.
出版信息
Eurasian J Med. 2018 Jun;50(2):116-121. doi: 10.5152/eurasianjmed.2018.0010. Epub 2018 Jun 1.
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, analgesic, and antipyretic effects. NSAIDs generally work by blocking the production of prostaglandins (PGs) through the inhibition of two cyclooxygenase enzymes. PGs are key factors in many cellular processes, such as gastrointestinal cytoprotection, hemostasis and thrombosis, inflammation, renal hemodynamics, turnover of cartilage, and angiogenesis. Interest has grown in the various effects of NSAIDs during the last decade. Epidemiological studies have revealed the reduced risk of several cancer types and neurodegenerative diseases by prolonged use of NSAIDs. Recent advances in the understanding of the cellular and molecular mechanisms of NSAIDs will accelerate the processes of discovery and clinical implementation. This review summarizes the molecular mechanisms of NSAIDs on the body systems.
摘要
非甾体抗炎药（NSAIDs）因其抗炎、镇痛和解热作用而被广泛使用。NSAIDs通常通过抑制两种环氧化酶来阻断前列腺素（PGs）的产生发挥作用。PGs是许多细胞过程中的关键因素，如胃肠道细胞保护、止血和血栓形成、炎症、肾血流动力学、软骨更新和血管生成。在过去十年中，人们对NSAIDs的各种作用的兴趣与日俱增。流行病学研究表明，长期使用NSAIDs可降低几种癌症类型和神经退行性疾病的风险。对NSAIDs细胞和分子机制认识的最新进展将加速发现和临床应用的进程。本综述总结了NSAIDs对身体系统的分子机制。
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