肾性骨营养不良中骨转换的新型生化血清标志物
New Biochemical Serum Markers of Boneturnover in Renal Osteodystrophy.
作者信息
Krintus Magdalena, Pater Agnieszka, Sypniewska Gra Yna, Nowacki Wies Aw
机构信息
Dept. of Laboratory Medicine, Ludwik Rydygier Medical University, Bydgoszcz Chairman: PhD.Prof.Gra¿yna Sypniewska.
Dept. of Orthopaedics and Traumatology, Ludwik Rydygier Medical University, Bydgoszcz Acting chairman: MD. Edward Szymkowiak.
出版信息
EJIFCC. 2004 Jun 17;15(2):23-28. eCollection 2004 Jun.
Renal osteodystrophy is a multifactorial disorder of bone remodelling that develops in patients with chronic renal failure. During the last few years numerous biochemical markers of bone turnover have been proposed for the non-invasive diagnosis of renal osteodystrophy. Several enzymes and matrix proteins produced by osteoblasts and osteoclasts, including collagen type I degradation products, have been recognized as circulating biochemical markers of both bone formation and bone resorption process. The aim of this article was to present and estimate the clinical utility of new serum markers of bone metabolism like bone specific alkaline phosphatase (bAP), procollagen type I extension peptides (PICP/PINP), osteocalcin (Oc), tartrate-resistant acid phosphatase (TRAP), procollagen type I crosslinked carboxyterminal telopeptide (ICTP), pyridinoline (PYR), deoxypyridinoline (DPD), C- or N-terminal telopeptides of type I collagen (CTx, NTx) and other potential markers in diagnosis of renal osteodystrophy in patients with chronic renal failure.
肾性骨营养不良是一种发生于慢性肾衰竭患者的骨重塑多因素紊乱疾病。在过去几年中，已经提出了许多骨转换的生化标志物用于肾性骨营养不良的无创诊断。成骨细胞和破骨细胞产生的几种酶和基质蛋白，包括I型胶原降解产物，已被认为是骨形成和骨吸收过程的循环生化标志物。本文的目的是介绍和评估骨代谢新血清标志物如骨特异性碱性磷酸酶（bAP）、I型前胶原延长肽（PICP/PINP）、骨钙素（Oc）、抗酒石酸酸性磷酸酶（TRAP）、I型前胶原交联羧基末端肽（ICTP）、吡啶啉（PYR）、脱氧吡啶啉（DPD）、I型胶原C末端或N末端肽（CTx、NTx）以及其他潜在标志物在慢性肾衰竭患者肾性骨营养不良诊断中的临床应用价值。
Zotero 插件