Kang Kai, Huang Yong-Hua, Li Hai-Peng, Guo Shu-Mei
Department of Gastroenterology, the First Hospital of Yulin City, Yulin, Shaanxi Province, China.
Department of Gastroenterology, Xingyuan Hospital of Yulin City, Shaanxi Province, Yulin, Shaanxi Province, China.
Arch Med Sci. 2018 Jun;14(4):752-759. doi: 10.5114/aoms.2018.73713. Epub 2018 Mar 2.
The long non-coding RNAs (lncRNAs) urothelial cancer associated 1 () and metastasis associated lung adenocarcinoma transcript 1 () are known to impact cancer cell regulation. The aim of the present study was to determine the relationship between the expression of these lncRNAs in esophageal squamous cell carcinoma (ESCC) tissues and disease prognosis.
The expression of and lncRNAs was assessed in ESCC and adjacent carcinoma tissues (5 cm away from the tumor) and evaluated in relation to overall survival (OS) and disease-free survival (DFS) of patients. This prospective study included 100 ESCC patients who were admitted to the First Hospital of Yulin City between January 2007 and January 2014.
The expression levels of and lncRNAs in ESCC tissues were significantly higher than those in adjacent carcinoma tissues, and there were statistically significant differences in TNM staging between the patients with high lncRNA expression and low lncRNA expression. The OS and DFS of patients with high and lncRNA expression levels were significantly shorter than those with low expression levels. Furthermore, the OS and DFS of ESCC patients appeared to be correlated with TNM staging.
These results imply that the up-regulation of and lncRNAs in ESCC tissues can impact the degree of tumor progression and is predictive of postoperative survival. Therefore, the expression levels of these lncRNAs can be used as measurement indexes to determine the prognosis of ESCC patients.
已知长链非编码RNA（lncRNAs）尿路上皮癌相关1（）和转移相关肺腺癌转录本1（）会影响癌细胞调控。本研究的目的是确定这些lncRNAs在食管鳞状细胞癌（ESCC）组织中的表达与疾病预后之间的关系。
评估ESCC组织和癌旁组织（距肿瘤5厘米处）中lncRNAs和的表达，并与患者的总生存期（OS）和无病生存期（DFS）相关联进行评估。这项前瞻性研究纳入了2007年1月至2014年1月间入住榆林市第一医院的100例ESCC患者。
ESCC组织中lncRNAs和的表达水平显著高于癌旁组织，lncRNA高表达患者与低表达患者之间的TNM分期存在统计学显著差异。lncRNA和高表达水平患者的OS和DFS显著短于低表达水平患者。此外，ESCC患者的OS和DFS似乎与TNM分期相关。
这些结果表明，ESCC组织中lncRNAs和的上调可影响肿瘤进展程度，并可预测术后生存期。因此，这些lncRNAs的表达水平可作为判断ESCC患者预后的测量指标。
