Liu Bo, Dong Xiaoqi, Xiao Yufei, Mao Xianya, Pan Wensheng, Un Das, Qin Guangming
Department of Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Oral Maxillofacial Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Arch Med Sci. 2018 Jun;14(4):766-772. doi: 10.5114/aoms.2018.76066. Epub 2018 Jun 25.
Prehypertension is highly prevalent. However, very few studies have evaluated the association of various metabolic risk factors in those with prehypertension and, more importantly, possible differences based on gender.
Data of clinical characteristics were collected from 3891 subjects. Risk factors were analyzed by multiple logistic regression analysis. The areas under receiver operating characteristic curves were compared to assess the discriminatory value of metabolic parameters for predicting prehypertension.
The incidence of prehypertension was 55.9% (66.9% of men, 41.1% of women). Prehypertensives showed clusters of metabolic associations including changes in the levels of plasma high-density lipoprotein cholesterol (OR = 1.550), triglycerides (OR = 1.141) and fasting blood glucose (OR = 1.320) after adjusting for age, sex, body mass index and smoking. The metabolic associations also showed differences based on gender. For instance, higher total cholesterol (OR = 1.602) was the most evident risk factor in men with prehypertension, while higher triglycerides (OR = 1.314) and lower high-density lipoprotein cholesterol (OR = 1.729) were the main risk factors in women.
Our study suggests that risk associations of prehypertension show gender differences. These results emphasize the importance of health education, active management of blood pressure and timely and effective treatment of abnormal lipid profile in subjects with prehypertension.
高血压前期非常普遍。然而，很少有研究评估高血压前期患者各种代谢危险因素之间的关联，更重要的是，基于性别的可能差异。
收集了3891名受试者的临床特征数据。通过多元逻辑回归分析对危险因素进行分析。比较受试者工作特征曲线下的面积，以评估代谢参数对预测高血压前期的判别价值。
高血压前期的发病率为55.9%（男性为66.9%，女性为41.1%）。在调整年龄、性别、体重指数和吸烟因素后，高血压前期患者表现出代谢关联聚类，包括血浆高密度脂蛋白胆固醇水平变化（OR = 1.550）、甘油三酯水平变化（OR = 1.141）和空腹血糖水平变化（OR = 1.320）。代谢关联也存在性别差异。例如，总胆固醇升高（OR = 1.602）是男性高血压前期最明显的危险因素，而甘油三酯升高（OR = 1.314）和高密度脂蛋白胆固醇降低（OR = 1.729）是女性的主要危险因素。
我们的研究表明，高血压前期的风险关联存在性别差异。这些结果强调了对高血压前期患者进行健康教育、积极管理血压以及及时有效治疗血脂异常的重要性。
