Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.
Department of Epidemiology and Health Statistics, School of Public Health, Bengbu Medical College, Bengbu, China.
J Hum Hypertens. 2021 Mar;35(3):207-214. doi: 10.1038/s41371-020-0321-9. Epub 2020 Mar 10.
Triglyceride-glucose (TyG) index is considered a simple and feasible indicator of insulin resistance (IR). This study aims to delve into the association and interaction of TyG index on the risk of prehypertension in Chinese adults. A community based cross-sectional survey conducted in Chinese population. Eligible participants were recruited, and questionnaire survey, anthropometric tests, and blood samples collection were performed. TyG index was obtained as ln [fasting TG(mg/dl) × FPG(mg/dl)/2]. Logistic regression model and the area under the receiver-operating characteristics (ROC) curves (AUC) were analyzed. Interaction analysis was conducted by calculating relative excess risk for interaction (RERI), attributable proportion for interaction (AP) as well as synergy index (SI). A total of 3115 recruited participants (1307 males and 1808 females) were aged 60.82 years on average. The prevalence of prehypertension reached 36.4% on the whole, 37.6% in male and 35.5% in female, respectively. The results of multivariable logistic regression model suggested that the adjusted OR for prehypertension was upregulated across TyG index quartiles, up to 2.06 (95% CI:1.53-2.77) for quartiles 4 versus quartiles 1. Furthermore, TyG index outperformed FPG (Z = 2.15, p = 0.032) and TG (Z = 6.10, p < 0.001) in discriminating prehypertension risk. Besides, TyG index with abdominal obesity (RERI:1.53, 95% CI:0.39-2.67; AP: 0.37, 95% CI: 0.16-0.59; SI:1.96, 95% CI:1.15-3.34) displayed a noticeable interaction on risk of prehypertension. Our study indicated that a higher TyG index rose the risk of prehypertension independently and synergistically with abdominal obesity in Chinese adults. Furthermore, it exhibited a higher predictability compared with conventional indices.
甘油三酯-葡萄糖（TyG）指数被认为是胰岛素抵抗（IR）的简单可行的指标。本研究旨在探讨 TyG 指数与中国成年人高血压前期风险的相关性和交互作用。这是一项在中国人群中进行的基于社区的横断面调查。合格的参与者被招募，并进行问卷调查、人体测量测试和血液样本采集。TyG 指数的计算方法为 ln[空腹甘油三酯（mg/dl）×空腹血糖（mg/dl）/2]。采用 logistic 回归模型和受试者工作特征（ROC）曲线下面积（AUC）进行分析。通过计算交互作用的相对超额危险度（RERI）、交互作用归因比例（AP）和协同指数（SI）来进行交互作用分析。共纳入 3115 名参与者（男性 1307 名，女性 1808 名），平均年龄为 60.82 岁。高血压前期的总体患病率为 36.4%，男性为 37.6%，女性为 35.5%。多变量 logistic 回归模型的结果表明，随着 TyG 指数四分位数的升高，高血压前期的调整比值比也升高，四分位数 4 与四分位数 1 相比，比值比为 2.06（95%CI：1.53-2.77）。此外，与 FPG（Z=2.15，p=0.032）和 TG（Z=6.10，p<0.001）相比，TyG 指数在预测高血压前期风险方面表现更好。此外，TyG 指数与腹型肥胖（RERI：1.53，95%CI：0.39-2.67；AP：0.37，95%CI：0.16-0.59；SI：1.96，95%CI：1.15-3.34）存在显著的交互作用，可显著增加高血压前期的风险。本研究表明，在中国成年人中，较高的 TyG 指数独立且与腹型肥胖协同升高高血压前期的风险。此外，它比常规指标具有更高的预测能力。
