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Therapeutic and immunological interventions in primary biliary cholangitis: from mouse models to humans.

作者信息

Tanaka Atsushi, Leung Patrick S C, Young Howard A, Gershwin M Eric

机构信息

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Division of Rheumatology Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA, USA.

出版信息

Arch Med Sci. 2018 Jun;14(4):930-940. doi: 10.5114/aoms.2017.70995. Epub 2017 Oct 24.

DOI:10.5114/aoms.2017.70995
PMID:30002712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6040118/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/ff798dff272d/AMS-14-30883-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/ee4294ed4768/AMS-14-30883-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/98d169f7a728/AMS-14-30883-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/9a7cb0286ca2/AMS-14-30883-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/81616c2191d0/AMS-14-30883-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/ff798dff272d/AMS-14-30883-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/ee4294ed4768/AMS-14-30883-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/98d169f7a728/AMS-14-30883-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/9a7cb0286ca2/AMS-14-30883-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/81616c2191d0/AMS-14-30883-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/6040118/ff798dff272d/AMS-14-30883-g005.jpg

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本文引用的文献

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J Autoimmun. 2017 May;79:1-3. doi: 10.1016/j.jaut.2017.02.004. Epub 2017 Feb 27.
2
Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy.原发性胆汁性胆管炎患者的肠道微生物群特征发生改变，熊去氧胆酸治疗后部分恢复。
Gut. 2018 Mar;67(3):534-541. doi: 10.1136/gutjnl-2016-313332. Epub 2017 Feb 17.
3
Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study.
回肠胆汁酸转运蛋白抑制剂 GSK2330672 对原发性胆汁性胆管炎瘙痒的影响：一项双盲、随机、安慰剂对照、交叉、2a 期研究。
Lancet. 2017 Mar 18;389(10074):1114-1123. doi: 10.1016/S0140-6736(17)30319-7. Epub 2017 Feb 8.
4
Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8 T cell activation.趋化因子受体CXCR3缺陷通过促进致病性CD8 T细胞活化而加剧小鼠自身免疫性胆管炎。
J Autoimmun. 2017 Mar;78:19-28. doi: 10.1016/j.jaut.2016.12.012. Epub 2017 Jan 24.
5
Primary Biliary Cholangitis Associated with Skin Disorders: A Case Report and Review of the Literature.原发性胆汁性胆管炎伴发皮肤疾病：一例病例报告及文献综述
Arch Immunol Ther Exp (Warsz). 2017 Aug;65(4):299-309. doi: 10.1007/s00005-016-0448-0. Epub 2017 Jan 25.
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The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis.抗线粒体抗体的特征与原发性胆汁性胆管炎的病因
Hepatology. 2017 May;65(5):1670-1682. doi: 10.1002/hep.29059. Epub 2017 Mar 31.
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