Ferry A P, Blair C J, Gragoudas E S, Volk S C
Arch Ophthalmol. 1985 Dec;103(12):1849-53. doi: 10.1001/archopht.1985.01050120083027.
Proton beam irradiation is one of the radiotherapeutic techniques currently used to manage uveal melanomas. Although this therapeutic modality has been in use for a decade and although nearly 500 patients have been so treated, there are only two published reports of the pathologic examination of these eyes. Key features found on pathologic examination of our patient's enucleated eye included vascular alterations in the tumor's blood supply, lymphocytic infiltrates, and lipoidal degeneration of tumor cells. The interval from therapy to enucleation in our patient was much longer than in the several previously reported cases, a factor allowing for the development of a more cumulative radiation effect on the tumor. The extent and degree of radiation-induced necrosis in our patient's tumor were more profound than in previous reports.
质子束照射是目前用于治疗葡萄膜黑色素瘤的放射治疗技术之一。尽管这种治疗方式已经使用了十年，并且已经治疗了近500名患者，但关于这些眼睛病理检查的已发表报告仅有两篇。在对我们患者摘除眼球的病理检查中发现的关键特征包括肿瘤血液供应的血管改变、淋巴细胞浸润以及肿瘤细胞的脂质变性。我们患者从治疗到眼球摘除的间隔时间比之前报道的几例病例长得多，这一因素使得对肿瘤产生了更累积的放射效应。我们患者肿瘤中放射诱导坏死的范围和程度比之前的报告更为严重。
