Gein S V, Kochina O A, Kuyukina M S, Ivshina I B
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia.
Perm State National Research University, Perm, Russia.
Bull Exp Biol Med. 2018 Jul;165(3):368-372. doi: 10.1007/s10517-018-4172-0. Epub 2018 Jul 12.
The glycolipid biosurfactant complex from actinobacterium Rhodococcus ruber IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines by peritoneal macrophages, detected in vivo, do not agree with the previously detected immunostimulatory activity of biosurfactants towards the immunocompetent cell cultures; this fact indicates an important role of the cell environment in the formation of immune response under the effect of bacterial glycolipids.
来自放线菌红球菌IEGM 231的糖脂生物表面活性剂复合物在腹腔注射和肌肉注射后会抑制先天免疫和适应性免疫参数。在体内检测到腹膜巨噬细胞的抗体产生、杀菌潜力和促炎细胞因子产生受到明显抑制，这与之前检测到的生物表面活性剂对免疫活性细胞培养物的免疫刺激活性不一致；这一事实表明细胞环境在细菌糖脂作用下免疫反应形成过程中具有重要作用。
