Dugue B, Meunier B
Biochem Biophys Res Commun. 1985 Nov 27;133(1):15-22. doi: 10.1016/0006-291x(85)91835-2.
Elliptinium acetate (NSC 264137) is an antineoplastic agent currently used in anticancer chemotherapy. We report here the first evidence that this drug is able to modify DNA models via a redox process with iron salts. In presence of iron (III) salts, EDTA and H2O2, 9-OH-NME degrades deoxyguanosine. The two main products are guanine and 8-hydroxydeoxyguanosine which result from the formation of hydroxyl radicals. The biological implications of this phenomenon are briefly discussed.
醋酸椭圆玫瑰树碱（NSC 264137）是一种目前用于抗癌化疗的抗肿瘤药物。我们在此报告首个证据，表明该药物能够通过与铁盐发生氧化还原过程来修饰DNA模型。在铁（III）盐、乙二胺四乙酸（EDTA）和过氧化氢存在的情况下，9-羟基-去甲椭圆玫瑰树碱会降解脱氧鸟苷。两种主要产物是鸟嘌呤和8-羟基脱氧鸟苷，它们是由羟基自由基的形成导致的。本文简要讨论了这一现象的生物学意义。
