Eschalier A, Lavarenne J, Dureng G, Rodriguez M, Tounissou P
J Pharmacol. 1984 Jul-Sep;15(3):301-8.
The effects of elliptinium were studied: Firstly, in the dog, in comparison with the effects of histamine, on heart rate and arterial blood pressure. Secondly, in guinea-pig isolated atria. When smaller doses were used (0.375; 0.75; 1.5 mg/kg) elliptinium only induced variations of heart rate. With the dose of 3 mg/kg hypotension and tachycardia appeared. The time-course of these effects was different from that of histamine (5 micrograms/kg): later onset and longer duration. Elliptinium was inactive in isolated guinea-pig atria, as observed in tracheal or digestive isolated smooth muscle. Thus, the cardiovascular activity of this antitumoral agent seems to implicate an indirect mechanism of action. This result is in accordance with the previous results obtained on bronchopulmonary system.
首先，在犬身上，将其与组胺对心率和动脉血压的作用进行比较。其次，在豚鼠离体心房上进行研究。当使用较小剂量（0.375；0.75；1.5毫克/千克）时，椭圆玫瑰树碱仅引起心率变化。当剂量为3毫克/千克时，出现低血压和心动过速。这些作用的时间过程与组胺（5微克/千克）不同：起效较晚且持续时间更长。如在气管或消化管离体平滑肌中所观察到的，椭圆玫瑰树碱对豚鼠离体心房无活性。因此，这种抗肿瘤药物的心血管活性似乎涉及一种间接作用机制。这一结果与先前在支气管肺系统上获得的结果一致。
