Peigneur Steve, de Lima Maria Elena, Tytgat Jan
Toxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg, PO Box 922, Herestraat 49, 3000 Leuven, Belgium; Laboratório de Venenos e Toxinas Animais, Dept de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo-Horizonte, MG, Brazil.
Laboratório de Venenos e Toxinas Animais, Dept de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo-Horizonte, MG, Brazil; Programa de Pós-graduação em Ciências da Saúde, Biomedicina e Medicina, Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Grupo Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
Toxicon. 2018 Sep 1;151:96-110. doi: 10.1016/j.toxicon.2018.07.008. Epub 2018 Jul 10.
In millions of years, spiders have optimized their venoms in order to assure successful prey capture and defence against predators. Spider venoms have become unique cocktails of biological active components enabling potentially interesting application for drug discovery or for agricultural purposes. The venom of Phoneutria nigriventer has been studied for over 60 years. This spider is responsible for a high number of envenomations with severe clinical manifestations in humans, which necessitates a comprehensive knowledge of its venom composition. With over 40 different neurotoxic peptides characterized so far and still many more awaiting identification, this venom is undoubtedly a pharmacological treasure. This review provides an overview of the Phoneutria nigriventer toxins known today and describes their mechanism of action at a molecular level. We critically discuss the potential of the Phoneutria nigriventer venom peptides as pharmaceutical tools or lead compounds for drug development.
数百万年来，蜘蛛一直在优化其毒液，以确保成功捕获猎物并抵御捕食者。蜘蛛毒液已成为独特的生物活性成分混合物，在药物发现或农业用途方面具有潜在的有趣应用。黑腹捕鸟蛛的毒液已被研究了60多年。这种蜘蛛导致人类大量中毒且有严重临床表现，因此有必要全面了解其毒液成分。迄今为止已鉴定出40多种不同的神经毒性肽，还有更多有待鉴定，这种毒液无疑是一座药理学宝库。本综述概述了目前已知的黑腹捕鸟蛛毒素，并在分子水平上描述了它们的作用机制。我们批判性地讨论了黑腹捕鸟蛛毒液肽作为药物开发的药学工具或先导化合物的潜力。
