Laboratory of Tumor Biology, Department of Experimental Biology, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic.
Laboratory of Tumor Biology, Department of Experimental Biology, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic.
Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2134-2139. doi: 10.1016/j.bbagen.2018.07.006. Epub 2018 Jul 9.
Sarcomas are rare tumors but represent the third most common malignancy in children. The cancer stem cell (CSC) paradigm is well established, and CSCs have been intensively studied in sarcomas in the past decade.
This review summarizes current knowledge on CSCs in sarcomas and provides new perspectives on the role of a deregulated stemness program in sarcomagenesis.
Cell surface markers have so far failed to specifically target sarcoma CSCs. Sarcomas likely arise from immature cells that undergo pathological reprogramming. Transcription factor Sox2, which is frequently upregulated in sarcomas, is directly involved in this process, and its crucial role in the acquisition and maintenance of the CSC phenotype has been demonstrated in various sarcomas.
Sox2 is a core functional regulator of the stem-like state and is an outstanding marker of sarcoma CSCs. Fluorescence protein-based reporters of Sox2 expression might provide useful tools for subsequent studies of sarcoma CSCs.
肉瘤是罕见的肿瘤，但在儿童中是第三大常见恶性肿瘤。癌症干细胞（CSC）范式已经确立，在过去十年中，CSC 已在肉瘤中得到深入研究。
本文综述了肉瘤中 CSC 的现有知识，并提供了对失调的干细胞特性在肉瘤发生中的作用的新视角。
迄今为止，细胞表面标志物未能特异性靶向肉瘤 CSC。肉瘤可能起源于经历病理性重编程的不成熟细胞。转录因子 Sox2 在肉瘤中经常上调，它直接参与了这个过程，其在获得和维持 CSC 表型中的关键作用已在各种肉瘤中得到证实。
Sox2 是干细胞样状态的核心功能调节剂，是肉瘤 CSC 的杰出标志物。基于荧光蛋白的 Sox2 表达报告基因可能为随后的肉瘤 CSC 研究提供有用的工具。
