Ji Tianjiao, Tan Xiaohua, Liu Leng, Gu Xinrui, Liu Li, Zheng Huanying, Zeng Hanri, Yang Qian, Li Hui, Xu Wenbo
Bing Du Xue Bao. 2016 Nov;32(6):713-20.
To understand the epidemiological etiology characteristics of hand, foot and mouth disease(HFMD)in Guangdong province, and to explore the risk change trend of the whole province. By using the descriptive epidemiological methods, the whole province’s incidence trend, population distribution and pathogenic form of HFMD were analyzed with the HFMD surveillance data,population data and geographic information of Guangdong province from 2008 to 2015.The analysis results show: A total of 2,133,722 cases of HFMD, including 5,066 severe cases and 259 death cases were reported in Guangdong province from 2008 to 2015.All the cities of Guangdong had HFMD cases, especially the Pearl River Delta Regions, which were on high-risk areas. There were two peaks every year, with the main peak of incidence occurred in spring and summer, and the sub peak occurred in autumn.Most cases were children aged<5years old, the proportion of this group in overall infections, the severe and death cases were 90.58%,95.93%and 97.30%,respectively,while the proportion for the children less than 3years old were 77.32% and 81.85%,respectively. The incidence of this disease among men was higher than that of women. Dynamic changes were presented between different years and seasons:CV-A16 was more popular in 2009,and enterovirus that none EV-A71 and none CV-A16 were predominant strains in 2013 and 2015.Especially in 2015,the proportion of other EV ranged as high as 71.97%.Besides,EV-A71 was the absolute predominance pathogen within death cases and was important pathogen in severe cases. This study suggests that HFMD epidemiology and laboratory monitoring in Guangdong Province should be strengthened, and provides scientific data support for further improvement of HFMD prevention and control strategies in Guangdong Province.
为了解广东省手足口病（HFMD）的流行病学病因特征，探索全省的风险变化趋势。采用描述性流行病学方法，利用2008 - 2015年广东省手足口病监测数据、人口数据和地理信息，分析全省手足口病的发病趋势、人群分布和致病形式。分析结果显示：2008 - 2015年广东省共报告手足口病病例2133722例，其中重症病例5066例，死亡病例259例。广东省各地市均有手足口病病例，尤其是珠江三角洲地区，属于高风险区域。每年有两个发病高峰，发病主峰出现在春夏季节，次峰出现在秋季。大部分病例为5岁以下儿童，该年龄段在总体感染、重症和死亡病例中的占比分别为90.58%、95.93%和97.30%，而3岁以下儿童的占比分别为77.32%和81.85%。男性发病率高于女性。不同年份和季节呈现动态变化：2009年CV - A16更为流行，2013年和2015年非EV - A71和非CV - A16的肠道病毒为优势毒株。特别是在2015年，其他肠道病毒的占比高达71.97%。此外，EV - A71是死亡病例中的绝对优势病原体，也是重症病例中的重要病原体。本研究提示应加强广东省手足口病的流行病学和实验室监测，为进一步完善广东省手足口病防控策略提供科学数据支持。
