Gu Xinrui, Zhao Hua, Ji Tianjiao, Li Qin, Ling Hua, Zhu Shuangli, Zhang Yong, Yang Qian, Song Yang, Huang Wei, Xu Wenbo
Bing Du Xue Bao. 2016 Nov;32(6):707-12.
In this study, the epidemiology of Hand-foot-mouth disease(HFMD)composition of enterovirus (EV) pathogen and VP1 coding gene of Enterovirus A71(EV-A71)were analyzed in Chongqing from 2014 to 2015,to provide a scientific basis for strategies of prevention and control of HFMD in Chongqing. It is reported that there were a total of 100,176 cases of HFMD, of which 284 cases of severe,37 cases of death in Chongqing.39counties(autonomous counties)of Chongqing have reported cases, and the urbans reported incidence rate(298.83/100,000)was significantly higher than the suburbs(103.37/100,000),children 3and under 3years old accounted for 83.21%%,and 5and under 5years old accounted for 95.64%of reported cases, the big peak of epidemics of HFMD was from April to July and the small peak took shape from October to November. Severe cases(96.83%)and deaths(100%)were concentrated in the age group of 5years old and below. The severe cases were mainly in the three districts, WanZhou District, Liangping County and FuLing District, accounting for 74.65% of reported cases, and death cases were widely distributed, scattered in 17 counties.7503nucleic acid of clinical specimens of HFMD were detected, suggested that EV-A71,CV-A16,non-EV-A71/CV-A16 of other EV accounted for 23.54%,33.21%,43.25% respectively,Non-EV-A71/ CV-A16 of other EV became the dominant pathogen of HFMD in Chongqing, but EV-A71 was still the dominant pathogen in severe and death cases. The results showed that 54 strains belonged to C4a and one strain belonged to B5 in the analyses of the VP1 sequences of 55 strains during2014-2015 in Chongqing. This study provides important epidemiological and etiological data for HFMD prevention and control strategies and reduction of severe and death caused by EV-A71 in Chongqing.
本研究对2014年至2015年重庆手足口病（HFMD）的流行病学、肠道病毒（EV）病原体组成以及肠道病毒A71（EV - A71）的VP1编码基因进行了分析，为重庆手足口病的防控策略提供科学依据。据报道，重庆手足口病病例共计100176例，其中重症284例，死亡37例。重庆39个区县（自治县）均有病例报告，城区报告发病率（298.83/10万）显著高于郊区（103.37/10万），3岁及以下儿童占报告病例的83.21%，5岁及以下儿童占95.64%。手足口病流行大高峰为4至7月，小高峰为10至11月。重症病例（96.83%）和死亡病例（100%）集中在5岁及以下年龄组。重症病例主要集中在万州区、梁平县和涪陵区三个区县，占报告病例的74.65%，死亡病例分布广泛，散在17个区县。共检测手足口病临床标本核酸7503份，结果显示EV - A71、CV - A16、其他肠道病毒非EV - A71/CV - A16分别占23.54%、33.21%、43.25%，其他肠道病毒非EV - A71/CV - A16成为重庆手足口病的主要病原体，但EV - A71仍是重症和死亡病例的主要病原体。结果显示，对重庆2014 - 2015年期间55株VP1序列分析，54株属于C4a，1株属于B5。本研究为重庆手足口病防控策略以及减少EV - A71所致重症和死亡提供了重要的流行病学和病原学数据。
