Lei Wei, Xia Yinlan, Wu Yang, Fu Gang, Ren Aishu
1 Department of Orthodontics, Stomatological Hospital of Chongqing Medical University , Chongqing, China .
2 Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences , Chongqing, China .
Genet Test Mol Biomarkers. 2018 Aug;22(8):465-473. doi: 10.1089/gtmb.2018.0037. Epub 2018 Jul 13.
We conducted a meta-analysis to investigate the associations of methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, and transcobalamin 2 (TCN2) C776G gene polymorphisms with nonsyndromic cleft lip with or without cleft palate (NSCL/P).
The PubMed, Web of Science, Embase, and Wiley Online Library databases and the China Biomedical Literature Service System (SinoMed) were searched for relevant articles to explore the associations between the MTR A2756G, MTRR A66G, and TCN2 C776G polymorphisms and the risk of NSCL/P. We performed overall comparisons and stratified analyses according to the ethnicity, type of NSCL/P, and Hardy-Weinberg equilibrium (HWE) of the control group. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were applied to estimate the associations of these gene polymorphisms with NSCL/P risk using fixed-effects or random-effects models incorporating five genetic models.
Ultimately, 12 articles were included in this study. The pooled results did not reveal a significant association of the MTR A2756G polymorphism with NSCL/P risk (G vs. A: OR = 0.95, 95% CI = 0.82-1.11, p = 0.55). Similar results were observed for the MTRR A66G polymorphism (G vs. A: OR = 0.99, 95% CI = 0.82-1.18, p = 0.72) and the TCN2 C776G polymorphism (G vs. C: OR = 0.95, 95% CI = 0.86-1.06, p = 0.37).
In summary, the MTR A2756G, MTRR A66G, and TCN2 C776G polymorphisms might not be associated with NSCL/P risk.
我们进行了一项荟萃分析，以研究甲硫氨酸合酶（MTR）A2756G、甲硫氨酸合酶还原酶（MTRR）A66G和转钴胺素2（TCN2）C776G基因多态性与非综合征性唇裂伴或不伴腭裂（NSCL/P）之间的关联。
检索PubMed、科学网、Embase和Wiley Online Library数据库以及中国生物医学文献服务系统（SinoMed），以查找相关文章，探讨MTR A2756G、MTRR A66G和TCN2 C776G基因多态性与NSCL/P风险之间的关联。我们根据种族、NSCL/P类型以及对照组的哈迪-温伯格平衡（HWE）进行了总体比较和分层分析。采用固定效应或随机效应模型，纳入五种遗传模型，应用合并比值比（OR）和95%置信区间（CI）来估计这些基因多态性与NSCL/P风险的关联。
最终，本研究纳入了12篇文章。汇总结果未显示MTR A2756G基因多态性与NSCL/P风险之间存在显著关联（G与A相比：OR = 0.95，95%CI = 0.82 - 1.11，p = 0.55）。对于MTRR A66G基因多态性（G与A相比：OR = 0.99，95%CI = 0.82 - 1.18，p = 0.72）和TCN2 C776G基因多态性（G与C相比：OR = 0.95，95%CI = 0.86 - 1.06，p = 0.37）也观察到了类似结果。
总之，MTR A2756G、MTRR A66G和TCN2 C776G基因多态性可能与NSCL/P风险无关。
