Department of Orthopedics, Chinese PLA General Hospital, Beijing, China.
Eur Rev Med Pharmacol Sci. 2018 Jul;22(1 Suppl):111-118. doi: 10.26355/eurrev_201807_15372.
To compare the mechanical behavior of a novel bioabsorbable cortical interference screw (BCIS) with bioabsorbable interference screw (BIS; Polylactate hydroxyapatite) used for anterior cruciate ligament (ACL) reconstruction in femoral and tibial fixation with doubled Achilles tendon graft in vitro.
30 paired goat knee specimens were harvested from 15 male sheep aged 18 months. All soft tissues were stripped from the bones of 20 paired specimens, and the last 10 paired specimens were stripped all soft tissues besides ACL (femur-ACL-tibia complex). The Achilles tendon was harvested as graft for ACL reconstruction. The specimens were divided into several groups: BCIS femoral fixation (group A, n=10), BIS femoral fixation (group B, n=10), BCIS tibial fixation (group C, n=10), BIS tibial fixation (group D, n=10), Group E is femur-ACL-tibia complex (n=10). Cyclic loading test was performed from 50 to 250 N at 1 Hz for 1000 cycles and followed by a load-to-failure test at 25 mm/sec. A paired t-test was used to compare the biomechanical properties of group A, B, E and group C, D, E.
No fixation structures failed during the cyclic phase. Cyclic displacement for group B was superior to group A, and showed statistically significant difference after 30, 100, 500, 1000 cycles. Group E got minimum cyclic displacements compared with group A and group B, and showed statistically significant difference after 500, 1000 cycles compared with group A. Cyclic displacement for group D was superior to group C, and showed statistically significant difference after 100, 500, 1000 cycles. Group E got minimum cyclic displacements compared with group C and group D, and showed statistically significant difference after 500,1000 cycles compared with group C. Regarding MFL, group A was superior to group B (572.10±111.12 N vs. 413.96±34.56 N, p=0.118), group E was superior to group A (599.74±85.45N vs. 572.10±111.12 N, p=0.992), and group C was superior to group D (802.88±240.07 N vs. 415.63±51.9 N, p<0.001), group C was superior to group E (802.88±240.07 N vs. 599.74±85.45 N, p=0.024). Regarding YL, group A was superior to group B (521.57±93.96 N vs. 366.99±44.66 N, p=0.109), group E was superior to group A (565.37±66.05 N vs. 521.57±93.96 N, p=0.952), and group C was superior to group D (735.63±242.91 N vs. 394.49±31.90 N, p<0.001), group C was superior to group E (735.63±242.91 N vs. 565.37±66.05 N, p=0.063). Regarding stiffness, group A was superior to group B (157.36±34.31 N/mm vs. 91.98±25.57 N/mm, p=0.001), group E was superior to group A (181.35±25.42 N vs. 157.36±34.31 N/mm, p=0.529), and group C was superior to group D (175.28±43.19 N/mm vs. 128.24±18.92 N/mm, p=0.032), group E was superior to group C (181.35±25.42 N/mm vs. 175.28±43.19 N/mm, p=0.995).
In vitro, this experimental study suggested the biomechanical properties of novel bioabsorbable cortical interference screw (BCIS) were superior to bioabsorbable interference screw (BIS) used for femoral and tibial anterior cruciate ligament (ACL) reconstruction in a goat knee model.
比较新型可吸收皮质骨干涉螺钉（BCIS）与生物可吸收干扰螺钉（BIS；聚乳酸羟基磷灰石）在前交叉韧带（ACL）重建中用于股骨和胫骨固定的力学行为，使用双倍跟腱移植物进行体外实验。
从 18 个月大的 15 只雄性绵羊中采集了 30 对羊膝关节标本。将 20 对标本的所有软组织从骨骼上剥离，最后 10 对标本除 ACL（股骨-ACL-胫骨复合体）外，所有软组织均被剥离。将跟腱作为 ACL 重建的移植物。将标本分为几组：BCIS 股骨固定组（A 组，n=10）、BIS 股骨固定组（B 组，n=10）、BCIS 胫骨固定组（C 组，n=10）、BIS 胫骨固定组（D 组，n=10）、股骨-ACL-胫骨复合体组（E 组，n=10）。在 1Hz 下从 50 至 250N 进行 1000 次循环的循环加载测试，然后以 25mm/sec 的速度进行至失效的负载测试。采用配对 t 检验比较 A、B、E 组和 C、D、E 组的生物力学性能。
在循环阶段没有固定结构失效。B 组的循环位移优于 A 组，在 30、100、500、1000 次循环后具有统计学显著差异。E 组与 A 组和 B 组相比，循环位移最小，在 500、1000 次循环后具有统计学显著差异。D 组的循环位移优于 C 组，在 100、500、1000 次循环后具有统计学显著差异。E 组与 C 组和 D 组相比，循环位移最小，在 500、1000 次循环后具有统计学显著差异。关于 MFL，A 组优于 B 组（572.10±111.12N 比 413.96±34.56N，p=0.118），E 组优于 A 组（599.74±85.45N 比 572.10±111.12N，p=0.992），C 组优于 D 组（802.88±240.07N 比 415.63±51.9N，p<0.001），C 组优于 E 组（802.88±240.07N 比 599.74±85.45N，p=0.024）。关于 YL，A 组优于 B 组（521.57±93.96N 比 366.99±44.66N，p=0.109），E 组优于 A 组（565.37±66.05N 比 521.57±93.96N，p=0.952），C 组优于 D 组（735.63±242.91N 比 394.49±31.90N，p<0.001），C 组优于 E 组（735.63±242.91N 比 565.37±66.05N，p=0.063）。关于刚度，A 组优于 B 组（157.36±34.31N/mm 比 91.98±25.57N/mm，p=0.001），E 组优于 A 组（181.35±25.42N 比 157.36±34.31N/mm，p=0.529），C 组优于 D 组（175.28±43.19N/mm 比 128.24±18.92N/mm，p=0.032），E 组优于 C 组（181.35±25.42N/mm 比 175.28±43.19N/mm，p=0.995）。
在体外实验中，本实验研究表明新型可吸收皮质骨干涉螺钉（BCIS）在前交叉韧带（ACL）重建中用于股骨和胫骨固定的生物力学性能优于生物可吸收干扰螺钉（BIS）。
