Gorban' E N
Biull Eksp Biol Med. 1985 Dec;100(12):643-5.
The effect of a single antioxidant (dibunol-D) injection (100 mg/kg body weight) on the functional activity of adrenal cortex (AC), thyroid gland (TG) and tropic hormone production by adenohypophysis (AH) has been studied in old and adult rats. For 48 hours following D administration two-phase changes in adrenocorticotropic function of AH and steroidogenesis were detected in the AC: activation during the first hours was followed by suppression 24 hours later, and recovery 48 hours later. Thyrotropic AH function and thyroidogenesis were found to be decreased during the first hours of D effect. Thyroidogenesis recovery by the end of the first day was delayed as compared to the recovery of AH thyrotropic function. It is suggested that the mechanisms of D action are based on its effects mediated by changes in the functional activity of endocrine glands and associated with resetting of endocrine regulation of body functions.
研究了单次注射抗氧化剂二丁基羟基甲苯-D（100毫克/千克体重）对老年和成年大鼠肾上腺皮质（AC）、甲状腺（TG）功能活性以及腺垂体（AH）促激素分泌的影响。在给予二丁基羟基甲苯-D后的48小时内，检测到AH促肾上腺皮质功能和AC类固醇生成出现两阶段变化：最初几小时激活，24小时后抑制，48小时后恢复。在二丁基羟基甲苯-D作用的最初几小时内，促甲状腺AH功能和甲状腺生成减少。与AH促甲状腺功能的恢复相比，甲状腺生成在第一天结束时的恢复延迟。提示二丁基羟基甲苯-D的作用机制基于其通过内分泌腺功能活性变化介导的效应，并与机体功能内分泌调节的重新设定有关。
