Department of Chemistry , Iowa State University , Ames , Iowa 50011 , United States.
J Phys Chem B. 2018 Aug 9;122(31):7747-7756. doi: 10.1021/acs.jpcb.8b05580. Epub 2018 Jul 25.
Magnetic ionic liquids (MILs), which incorporate paramagnetic ions, promise to minimize manual user intervention, decrease extraction times, and facilitate rapid recovery of the analyte-enriched extraction solvent. If, however, fluorescence is employed in the downstream analysis of an analyte tagged with a fluorophore, the paramagnetic ion may quench fluorescence by introducing new nonradiative processes. Thus, it is necessary to employ a paramagnetic ion that offers a compromise between possessing a high magnetic moment and not introducing new nonradiative channels. Mn(II), Fe(III), Co(II), and Ni(II) are considered in combination with phosphonium cations and anionic ligands based upon halides or hexafluoroacetylacetonate. Among the possibilities examined, MILs containing Mn(II) provide the best alternative for a model system involving DNA.
磁性离子液体（MILs）结合了顺磁离子，有望最大限度地减少手动用户干预，缩短提取时间，并促进分析物富集的萃取溶剂的快速回收。然而，如果在下游分析中使用荧光标记的分析物，顺磁离子可能会通过引入新的非辐射过程来猝灭荧光。因此，有必要选择一种顺磁离子，它在具有高磁矩和不引入新的非辐射通道之间取得平衡。考虑将 Mn(II)、Fe(III)、Co(II) 和 Ni(II)与磷翁阳离子和基于卤化物或六氟乙酰丙酮的阴离子配体结合使用。在所检查的可能性中，含 Mn(II)的 MILs 为涉及 DNA 的模型系统提供了最佳选择。
