Department of Chemistry and Pharmacy , Ludwig-Maximilians-University , Butenandtstraße 5-13 , 81377 Munich , Germany.
Org Lett. 2018 Aug 3;20(15):4654-4658. doi: 10.1021/acs.orglett.8b01961. Epub 2018 Jul 13.
For the first time, an approach to 3,4-disubstituted thietes was developed through two complementary paths. While the first one relies on α-metalation, the second is based on direct C-H functionalization. A new library of sophisticated sulfur-containing four-membered rings is described, paving the way to new bioactive analogues and small heterocycle incorporation.
首次通过两种互补途径开发了 3,4-二取代噻唑的方法。其中一种方法依赖于α-金属化，另一种方法则基于直接 C-H 功能化。描述了一个新的复杂含硫四元环库，为新的生物活性类似物和小杂环的引入铺平了道路。
