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每月抗血管内皮生长因子治疗增生型糖尿病视网膜病变可逆转视网膜血管渗漏和阻止进行性视网膜无灌注。

Reversal of Retinal Vascular Leakage and Arrest of Progressive Retinal Nonperfusion With Monthly Anti-Vascular Endothelial Growth Factor Therapy for Proliferative Diabetic Retinopathy.

机构信息

Department of Ophthalmology, Weill Cornell Medical College, New York, New York.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois.

出版信息

Retina. 2018 Sep;38(9):e74-e75. doi: 10.1097/IAE.0000000000002261.

DOI:10.1097/IAE.0000000000002261
PMID:30005003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6103792/
Abstract

We report a case of proliferative diabetic retinopathy (PDR) with severe, vision-threatening retinal non-perfusion (RNP) in which anti-vascular endothelial growth factor (VEGF) therapy resulted not only PDR reversal but also in arrest of RNP and resolution of retinal vascular leakage which had previously preceded vascular dropout and progressive RNP in the same patient.

摘要

我们报告了一例增殖型糖尿病性视网膜病变(PDR)伴严重、威胁视力的视网膜无灌注(RNP),抗血管内皮生长因子(VEGF)治疗不仅逆转了 PDR,还阻止了 RNP 的进展,并解决了视网膜血管渗漏,此前该患者已经出现了血管闭塞和进行性 RNP。

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本文引用的文献

1
Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections.玻璃体内注射抗血管内皮生长因子治疗糖尿病视网膜病变后的视网膜再灌注
Clin Ophthalmol. 2017 Jan 21;11:193-200. doi: 10.2147/OPTH.S118807. eCollection 2017.
2
Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.全视网膜光凝与玻璃体内注射雷珠单抗治疗增殖性糖尿病视网膜病变的随机临床试验
JAMA. 2015 Nov 24;314(20):2137-2146. doi: 10.1001/jama.2015.15217.
3
Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results From the VISTA and VIVID Studies.玻璃体内注射阿柏西普治疗糖尿病性黄斑水肿:VISTA 和 VIVID 研究的 100 周结果。
Ophthalmology. 2015 Oct;122(10):2044-52. doi: 10.1016/j.ophtha.2015.06.017. Epub 2015 Jul 18.
4
Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema.血管内皮生长因子中和作用可延缓糖尿病黄斑水肿患者视网膜无灌注进展。
Ophthalmology. 2014 Sep;121(9):1783-9. doi: 10.1016/j.ophtha.2014.03.021. Epub 2014 Apr 24.
5
Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE.雷珠单抗治疗糖尿病性黄斑水肿:两项 III 期随机临床试验(RISE 和 RIDE)的结果。
Ophthalmology. 2012 Apr;119(4):789-801. doi: 10.1016/j.ophtha.2011.12.039. Epub 2012 Feb 11.