Costa-Orlandi Caroline B, Mordorski Breanne, Baltazar Ludmila M, Mendes-Giannini Maria José S, Friedman Joel M, Nosanchuk Joshua D, Friedman Adam J
J Drugs Dermatol. 2018 Jul 1;17(7):717-720.
Topical antimicrobials are the ideal mode of onychomycosis treatment for efficient drug delivery and avoidance of sytemic effects associated with oral medications. However, high treatment costs, tissue penetration limitations, and low cure rates have continued to pose major challenges. To capitalize on the progress made by topical efinaconazole solution, efinaconazole was combined with inexpensive, previously-characterized nitric oxide releasing nanoparticles (NO-np), which have been shown to offer sustained nitric oxide release over time and enhanced barrier penetration, while exerting broad spectrum antimicrobial and immunomodulating properties. NO-np were combined with efinaconazole in varying concentrations and applied against reference strains of Trichophyton rubrum using a checkerboard method. Results demonstrated synergism of NO-np+efinaconazole against T. rubrum, which is noteworthy given the barriers present in the topical treatment of onychomycosis, and the multiple potential benefits offered by NO-np. Overall, this study illustrates the untapped potential of nanotechnology in the treatment of disorders of the skin, hair, and nails where drug delivery remains a challenge. J Drugs Dermatol. 2018;17(7):717-720.
局部用抗菌药物是治疗甲癣的理想方式，可实现高效给药并避免口服药物相关的全身效应。然而，高治疗成本、组织渗透限制和低治愈率一直是主要挑战。为利用局部用艾氟康唑溶液取得的进展，将艾氟康唑与廉价的、先前已表征的一氧化氮释放纳米颗粒（NO-np）相结合，这些纳米颗粒已被证明可随时间持续释放一氧化氮并增强屏障穿透能力，同时具有广谱抗菌和免疫调节特性。将不同浓度的NO-np与艾氟康唑混合，并使用棋盘法对红色毛癣菌参考菌株进行应用测试。结果表明，NO-np+艾氟康唑对红色毛癣菌具有协同作用，鉴于甲癣局部治疗存在的障碍以及NO-np提供的多种潜在益处，这一点值得关注。总体而言，本研究说明了纳米技术在治疗皮肤、毛发和指甲疾病方面尚未开发的潜力，在这些疾病中药物递送仍然是一个挑战。《皮肤药物学杂志》。2018年；17(7):717 - 720。
