Kerdel Francisco, Don Frank
J Drugs Dermatol. 2018 Jul 1;17(7):737-742.
Psoriasis is a chronic, immune-mediated, inflammatory disease that if left untreated can result in prolonged subclinical inflammation that affects a variety of organs, including the heart, liver, kidney, and intestines, as well as joints and muscles. Relatedly, psoriasis significantly increases patients' risks for developing certain comorbidities. Disease progression in psoriasis is unpredictable, and some patients have mild disease that is stable for many years, while in others, mild disease quickly progresses to moderate-to-severe psoriasis. Adding to the complexity of this disease, subclinical systemic inflammation is present in patients with either mild or moderate-to-severe psoriasis. In this review, key factors in psoriasis progression, including the role that systemic inflammation has in psoriasis pathogenesis and the development of comorbidities, are highlighted along with the ability of various therapies to potentially stop or slow the progression of psoriasis and its associated comorbidities. Additionally, practical guidance is provided for physicians regarding treatment and monitoring of disease progression based on psoriasis severity and the risk of comorbidities. J Drugs Dermatol. 2018;17(7):737-742.
银屑病是一种慢性、免疫介导的炎症性疾病，如果不进行治疗，可能会导致长期的亚临床炎症，影响包括心脏、肝脏、肾脏和肠道在内的多种器官，以及关节和肌肉。与此相关的是，银屑病会显著增加患者发生某些合并症的风险。银屑病的疾病进展是不可预测的，一些患者病情较轻且多年稳定，而另一些患者的轻度疾病会迅速进展为中度至重度银屑病。这种疾病的复杂性还在于，轻度或中度至重度银屑病患者均存在亚临床全身炎症。在本综述中，强调了银屑病进展的关键因素，包括全身炎症在银屑病发病机制和合并症发生中的作用，以及各种治疗方法潜在阻止或减缓银屑病及其相关合并症进展的能力。此外，还为医生提供了基于银屑病严重程度和合并症风险的疾病治疗及监测的实用指导。《皮肤药物学杂志》。2018年；17(7):737 - 742。
