Gunt Hemali B, Levy Stanley B, Lutrario Celeste A
J Drugs Dermatol. 2018 Jul 1;17(7):758-764.
The objective of this 6-week clinical study was to demonstrate the effectiveness of a natural ingredient-based moisturizing cream versus a colloidal oatmeal moisturizing cream in improving the hydration, barrier function, appearance, and feel of dry leg skin. Thirty-two subjects completed the study. After a 5-day washout, subjects used the natural ingredient-based moisturizing cream and oatmeal-containing cream on randomly-assigned legs twice a day for a period of three weeks. For the following two weeks subjects did not use any moisturizer on their legs. Skin moisture measurements showed a statistically significant increase in hydration for both products at all time points during the treatment phase of the study. Both products reduced transepidermal water loss measurements during the treatment phase of the study, showing their abilities to improve stratum corneum barrier function. Clinical evaluations showed that both products significantly decreased visual dryness and tactile roughness during the treatment phase. Improvements in the assessed clinical parameters persisted even after treatment cessation. In conclusion, the natural ingredient-based moisturizing cream was highly effective in providing moisturization and improving the skin barrier of subjects with very dry leg skin. It also produced significant improvements in visual dryness and tactile roughness that persisted during regression. Overall, these results show that the natural ingredient-based moisturizing cream delivers comparable benefits to that of a colloidal oatmeal-containing benchmark product and is an option for health care providers and consumers who seek relief from dry skin and prefer a product with all-natural ingredients. J Drugs Dermatol. 2018;17(7):758-764.
这项为期6周的临床研究的目的是证明一款基于天然成分的保湿霜与一款胶态燕麦保湿霜相比，在改善腿部干性皮肤的水合作用、屏障功能、外观及触感方面的有效性。32名受试者完成了该研究。经过5天的洗脱期后，受试者在随机分配的腿上每天使用两次基于天然成分的保湿霜和含燕麦的保湿霜，为期三周。在接下来的两周里，受试者腿部不使用任何保湿剂。皮肤水分测量结果显示，在研究的治疗阶段，两种产品在所有时间点的水合作用均有统计学上的显著增加。在研究的治疗阶段，两种产品均降低了经表皮水分流失测量值，显示出它们改善角质层屏障功能的能力。临床评估表明，在治疗阶段，两种产品均显著降低了视觉干燥度和触觉粗糙度。即使在停止治疗后，所评估的临床参数的改善仍持续存在。总之，基于天然成分的保湿霜在为腿部皮肤非常干燥的受试者提供保湿和改善皮肤屏障方面非常有效。它还在视觉干燥度和触觉粗糙度方面产生了显著改善，且在恢复阶段持续存在。总体而言，这些结果表明，基于天然成分的保湿霜与含胶态燕麦的基准产品具有相当的效果，对于寻求缓解皮肤干燥并偏好全天然成分产品的医疗保健提供者和消费者来说是一种选择。《皮肤药物学杂志》。2018年；17(7):758 - 764。
