Goedert M, Lightman S L, Mantyh P W, Hunt S P, Emson P C
Brain Res. 1985 Dec 9;358(1-2):59-69. doi: 10.1016/0006-8993(85)90948-5.
In the rat hypothalamus, cell bodies containing neurotensin-like immunoreactivity were mainly found in the medial preoptic area, the periventricular nucleus, the paraventricular nucleus, the supraoptic nucleus and the arcuate nucleus. [3H]neurotensin binding sites were observed throughout the hypothalamus with a dense accumulation of silver grains over the paraventricular nucleus, the arcuate nucleus and the median eminence region. By radioimmunoassay neurotensin-like immunoreactivity was also found in the neurointermediate lobe of the pituitary gland of various mammalian species and in human postmortem posterior pituitary glands. In the rat studies involving pituitary stalk transections and the neurotoxin monosodium glutamate indicated the presence of a neurotensinergic pathway from the arcuate nucleus to the neurointermediate lobe of the pituitary gland. [3H]neurotensin binding sites were found to be concentrated over the intermediate lobe of the pituitary gland and their presence was not affected by pituitary stalk transection, indicating their localization on endocrine cells of the intermediate lobe of the pituitary gland.
在大鼠下丘脑中，含有神经降压素样免疫反应性的细胞体主要见于视前内侧区、室周核、室旁核、视上核和弓状核。在下丘脑各处均观察到[3H]神经降压素结合位点，室旁核、弓状核和正中隆起区域有密集的银颗粒聚集。通过放射免疫测定法，在各种哺乳动物物种的垂体神经中间叶以及人类尸检后的垂体后叶中也发现了神经降压素样免疫反应性。在大鼠中进行的涉及垂体柄横断和神经毒素谷氨酸单钠的研究表明，存在一条从弓状核到垂体神经中间叶的神经降压素能通路。[3H]神经降压素结合位点被发现集中在垂体中间叶，并且其存在不受垂体柄横断的影响，表明它们定位于垂体中间叶的内分泌细胞上。
