Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan; Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan.
Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan.
Clin Neurophysiol. 2018 Sep;129(9):1899-1906. doi: 10.1016/j.clinph.2018.06.018. Epub 2018 Jul 3.
This study aimed to investigate the association between mismatch negativity (MMN) and volumes of several brain regions measured using a semi-automated method in patients with schizophrenia and healthy controls.
MMN in response to duration deviants and magnetic resonance imaging were acquired from 36 schizophrenia patients and 14 healthy controls. FreeSurfer was used for volumetric analysis. MMN amplitudes, brain volumes and their association were compared between schizophrenia and controls. Correlation analysis and multiple linear regression analysis were used to examine the correlated variables of MMN.
MMN amplitude was significantly lower in the schizophrenia group. In schizophrenia, MMN was positively correlated with age and negatively correlated with left hippocampal and right pars opercularis volumes. The association between left hippocampal volume and MMN in schizophrenia remained significant after controlling for potential confounders.
Smaller hippocampal volume may play a role in the abnormal manifestation of MMN in schizophrenia.
The significant association between MMN and left hippocampal volume may suggest unique neurobiological contribution of hippocampus in auditory processing in schizophrenia.
本研究旨在探讨精神分裂症患者和健康对照者中，使用半自动方法测量的错配负波（MMN）与几个脑区体积之间的关系。
对 36 名精神分裂症患者和 14 名健康对照者进行了 MMN 对时长偏差的反应和磁共振成像。使用 FreeSurfer 进行容积分析。比较精神分裂症组和对照组的 MMN 振幅、脑体积及其相关性。采用相关分析和多元线性回归分析来检验 MMN 的相关变量。
精神分裂症组的 MMN 振幅明显较低。在精神分裂症中，MMN 与年龄呈正相关，与左海马体和右侧额下回体积呈负相关。在控制了潜在混杂因素后，精神分裂症患者左海马体体积与 MMN 之间的相关性仍然显著。
较小的海马体体积可能在精神分裂症中 MMN 异常表现中起作用。
MMN 与左海马体体积之间的显著相关性可能表明海马体在精神分裂症听觉处理中具有独特的神经生物学贡献。
