[人类B淋巴细胞血液病中的磷脂酰乙醇胺甲基化酶和环核苷酸磷酸二酯酶活性]
[Phosphatidylethanolamine methylase and cyclic nucleotide phosphodiesterase activities in human B lymphoid hemopathies].
作者信息
Pacheco Y, Magaud J P, Dubois M, French M, Fonlupt P, Prigent A F, Rey C, Germain D, Pacheco H
出版信息
C R Acad Sci III. 1985;301(16):711-6.
Phospholipid methylase and cyclic nucleotide phosphodiesterase activities were studied in human B lymphoïd hemopathies (51 patients: acute lymphoblastic leukemia, B lymphoma, chronic lymphocytic leukemia, hairy cell leukemia) and compared with activities in lymphoblastïd and Burkitt lymphoma cell lines and with normal B lymphocytes: methylase activity proved to be lower in ALL and high grade lymphoma and inversely related to the percent of cells in S phase state; the A/G ratio of phosphodiesterases was low in ALL and CLL and high in hairy cell leukemia and it was related to the percent of cells in S phase state.
对人类B淋巴细胞血液病（51例患者：急性淋巴细胞白血病、B淋巴瘤、慢性淋巴细胞白血病、毛细胞白血病）中的磷脂甲基化酶和环核苷酸磷酸二酯酶活性进行了研究，并与淋巴母细胞样和伯基特淋巴瘤细胞系以及正常B淋巴细胞中的活性进行了比较：结果表明，急性淋巴细胞白血病和高级别淋巴瘤中的甲基化酶活性较低，且与处于S期状态的细胞百分比呈负相关；磷酸二酯酶的A/G比值在急性淋巴细胞白血病和慢性淋巴细胞白血病中较低，在毛细胞白血病中较高，且与处于S期状态的细胞百分比有关。
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