Department of Radiation Oncology, University of Alabama at Birmingham, Hazelrig Salter Radiation Oncology Center, 1700 6th Avenue South, Birmingham, AL 35233, USA.
Department of Radiation Oncology, University of Alabama at Birmingham, The Kirklin Clinic at Acton Road, 2145 Bonner Way, Birmingham, AL 35243, USA.
Surg Clin North Am. 2018 Aug;98(4):801-817. doi: 10.1016/j.suc.2018.03.010. Epub 2018 May 28.
Throughout various eras of breast cancer therapy, postmastectomy radiation therapy (PMRT) has played an important role in the treatment of locally advanced breast cancer. PMRT decreases locoregional recurrence and may improve overall survival in patients with tumors over 5 cm or positive lymph nodes. As novel cancer therapies improve survival in breast cancer, the role of radiation therapy is evolving. Individualized recommendations for PMRT dependent on pathologic response after neoadjuvant systemic therapy are under investigation. This review summarizes the role of PMRT during breast cancer therapy and discusses open questions that may change the landscape of future breast cancer treatment.
在乳腺癌治疗的各个时代，乳腺癌根治术后放射治疗（PMRT）在局部晚期乳腺癌的治疗中发挥了重要作用。PMRT 可降低局部区域复发率，并可能改善肿瘤大于 5 厘米或淋巴结阳性患者的总生存率。随着新型癌症治疗方法提高乳腺癌患者的生存率，放射治疗的作用也在不断发展。新辅助全身治疗后根据病理反应进行个体化 PMRT 推荐的研究正在进行中。本文综述了 PMRT 在乳腺癌治疗中的作用，并讨论了可能改变未来乳腺癌治疗格局的悬而未决的问题。
